Number, distribution and neuropeptide content of rat knee joint afferents

Journal of Anatomy
P T Salo, E Theriault

Abstract

Retrograde tracing with Fluoro-Gold was used to identify the complete population of knee joint afferents in the lumbar dorsal root ganglia of adult female Wistar rats. There was an average of 581 +/- 31 (mean +/- S.D.) afferents supplying each joint. These were found distributed from L1 to L5 with the great majority localised in the L3 and L4 ganglia. Electron microscopy of the posterior articular nerve of the knee revealed an average of 103 +/- 15 (mean +/- S.D.) myelinated and 513 +/- 39 unmyelinated axonal profiles. Since about 50-60% of the unmyelinated profiles would be expected to be sympathetic efferents, these numbers are consistent with the numbers of afferents found by Fluoro-Gold retrograde tracing and suggest that the posterior articular nerve contains about 50% of the total number of knee joint afferents in the rat. Immunohistochemistry revealed that an average of 10% of identified joint afferents expressed substance P-like immunoreactivity and that 33% expressed calcitonin gene-related peptide-like immunoreactivity.

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Citations

Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Paul T SaloRobert C Bray
May 25, 1999·Journal of Anatomy·M G Catre, P T Salo
Jun 27, 2006·Sports Medicine·Scott C WearingAndrew P Hills
Sep 28, 2012·Phytotherapy Research : PTR·Catherine E FerlandPascal Vachon
Sep 24, 2004·Neuroscience·S P IvanaviciusP I Mapp
Oct 21, 2004·Pain·Janet FernihoughJanet Winter
Apr 1, 2016·Molecular Pain·Ines da Silva SerraEwan St John Smith
Dec 14, 2017·International Journal of Molecular Sciences·Rita de Cássia da Silveira E SáDamião Pergentino de Sousa
Aug 14, 2018·Science Advances·Michael MousseauTuan Trang
Oct 6, 1998·The Journal of Bone and Joint Surgery. American Volume·T Hogervorst, R A Brand

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