Number of contractions to maintain mass and force of a denervated rat muscle

Muscle & Nerve
Douglas E DowRobert G Dennis

Abstract

Within 5 weeks, denervated extensor digitorum longus (EDL) muscles of rats lose 66% of mass, 91% of force, and 76% of fiber cross-sectional area (CSA). We previously determined the parameters of electrical stimulation for denervated rat EDL muscles to generate tetanic contractions sufficient to maintain mass and force close to control values. Using these parameters, we tested the hypothesis that a range exists for number of contractions per day, below and above which values for mass, maximum force, and fiber CSA are lower than values for innervated control muscles. For 5 weeks, denervated EDL muscles were stimulated to generate between 25 and 5000 contractions daily with contractions separated by constant intervals of rest, repeated 24 h per day. Force was not maintained with fewer than 200 or more than 800 contractions daily, whereas mass and fiber CSA were not maintained with fewer than 50 contractions daily. Protocols of stimulation that maintain muscle mass and force during prolonged periods of denervation may minimize problems clinically associated with denervation atrophy.

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Citations

Oct 10, 2013·Photomedicine and Laser Surgery·Shimon Rochkind, Asher Shainberg
Sep 18, 2007·Tissue Engineering·Robert G Dennis, Douglas E Dow
Oct 8, 2009·Tissue Engineering. Part C, Methods·Kenneth DonnellyKeith Baar
Jun 4, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Douglas E DowJohn A Faulkner
Jun 15, 2006·Plastic and Reconstructive Surgery·Gregory H BorschelDavid L Brown
Sep 11, 2008·Artificial Organs·Stanley Salmons, Jonathan C Jarvis
Feb 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Bradley A ClarkTatiana Y Kostrominova
Jan 1, 2011·Journal of medical and biological engineering·Michael P WillandJames R Bain
Apr 28, 2012·Journal of Molecular Histology·Ludimila Canuto CabeçoMaeli Dal-Pai-Silva
Sep 13, 2008·American Journal of Physical Medicine & Rehabilitation·Silvana Coca LimaViviane Balisardo Minamoto
Jul 31, 2013·Hand Clinics·Christine B Novak, Rebecca L von der Heyde
May 12, 2015·Muscle & Nerve·Fernanda M FaturiThiago L Russo
Oct 22, 2008·Hand Clinics·Samuel C LienWilliam M Kuzon
Apr 11, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mayvi AlvaradoPablo Pacheco
Jun 20, 2008·Muscle & Nerve·Zoe AshleyStanley Salmons
Oct 27, 2010·Lasers in Surgery and Medicine·Davilene Gigo-BenatoNivaldo Antonio Parizotto
Nov 27, 2014·Journal of Tissue Engineering and Regenerative Medicine·Wesley N SivakKacey G Marra
Jun 7, 2015·Journal of Neuroengineering and Rehabilitation·Karin PieberOthmar Schuhfried
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Sep 2, 2016·American Journal of Physical Medicine & Rehabilitation·Clara Maria Pinheiro-Dardis, Thiago Luiz Russo
Jan 26, 2017·Muscle & Nerve·Clara M Pinheiro-DardisThiago L Russo
Mar 28, 2017·Muscle & Nerve·Eun Sil KohJae-Young Lim
Aug 24, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S M AlvesR Barbosa
Jan 23, 2013·Acta Cirúrgica Brasileira·Fábio Oliveira MacielBárbara Moraes Souza

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