Number of lymph node metastases is better predictor of prognosis than level of lymph node metastasis in patients with node-positive colon cancer

Journal of the American College of Surgeons
On SuzukiSatoshi Kondo

Abstract

Lymph node metastasis is the most important prognostic factor for colon cancer patients. Survival is also related to the number and level of positive lymph nodes (PLNs). Definitions of degree of PLNs for colon cancer differ greatly between the number and level of PLNs. The aim of this study is to compare number and level of PLNs to see which is a better predictor of prognosis for node-positive colon cancer. One hundred eighteen patients underwent histologically curative resection for node-positive colon cancer. We calculated the cumulative 5-year survival rates and examined prognostic factors for multivariate analysis based on the number and level of PLNs and additional factors. The number of PLNs was classified as either one to three PLNs or more than four PLNs, and level of PLNs was classified as either Level I (pericolic lymph node metastasis) or Level II (lymph node metastasis along the major named vessel supplying the tumor, and that around the origin of a main artery). Cumulative 5-year survival rates were statistically different between the 1 to 3 PLNs group and the more than 4 PLNs group, but not significantly different between Level I group and Level II group. Multivariate analysis showed that number, not level, of PLN...Continue Reading

References

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Citations

Jul 3, 2009·Diseases of the Colon and Rectum·Carlos A VaccaroFernando A Bonadeo
Jan 15, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C W AngP S Rooney
May 31, 2011·Journal of Hematology & Oncology·Chandrakumar ShanmugamUpender Manne
Nov 7, 2007·Annals of Surgical Oncology·Sherry J LimGeorge J Chang
May 9, 2013·World Journal of Surgery·Jamie Murphy, Tonia Young-Fadok
Jun 28, 2015·American Journal of Surgery·Ahmet Ziya BaltaOzgur Dandin
Apr 24, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P M van SchaikK Bosscha
Mar 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qing-guo LiSan-jun Cai
Apr 2, 2008·Journal of Immunological Methods·Mona KarlssonOla Winqvist
Oct 16, 2013·Cancer Treatment Reviews·Wouter WillaertWim Ceelen
Jul 12, 2019·International Journal of Colorectal Disease·Seung-Seop YeomYoung Jin Kim
Jan 13, 2015·World Journal of Gastroenterology : WJG·Wouter Willaert, Wim Ceelen
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yavuz OzdemirErgun Yucel
Jun 10, 2020·International Journal of Colorectal Disease·Li M WangShige K Yamaguchi
Nov 3, 2021·Nano Convergence·Jessica A Kemp, Young Jik Kwon

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