PMID: 3748271Jul 1, 1986Paper

Number of neurons in nucleus locus ceruleus in demented and non-demented patients: rapid estimation and correlated parameters

Neurobiology of Aging
W Bondareff, C Q Mountjoy

Abstract

The total number of neurons in nucleus locus ceruleus (nLC) was counted in 20 patients with dementia (19 with dementia of the Alzheimer type) and 10 non-demented patients with the assistance of an image analyzer. The average number of neurons in a single representative section of nLC through the site of maximal neuronal density was then determined in each case. Both the mean total neuronal count and the average number of neurons in single sections correlated significantly with age, severity of dementia and length of nLC. The mean total number of neurons for demented (5571.700 +/- 4151.073) and non-demented (12533.700 +/- 2336.320) subjects differed significantly. The mean number of neurons derived by averaging counts of single representative sections from demented subjects (67.9 +/- 31.19) correlated significantly with the total number of nLC neurons determined by Quantimet-assisted analysis and differed significantly from the mean number of neurons derived by averaging counts of single representative sections of non-demented subjects of comparable age (110.0 +/- 16.59). With both methods of estimating neuronal numbers, the number of surviving nLC neurons in demented patients fell into 2 distinct groups, with cut-off points at ...Continue Reading

References

Sep 1, 1979·Journal of Neuropathology and Experimental Neurology·N Vijayashankar, H Brody
Jan 1, 1987·Alzheimer Disease and Associated Disorders·W BondareffD L Hauser
Sep 1, 1970·Journal of the Neurological Sciences·B E TomlinsonM Roth
Jul 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·G BlessedM Roth
Jan 1, 1984·Neurobiology of Aging·H C ChuiU Slager
Mar 1, 1981·Journal of the Neurological Sciences·B E TomlinsonG Blessed
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

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Citations

Nov 1, 1989·Neurobiology of Aging·W BondareffD L Hauser
Aug 1, 1992·Psychoneuroendocrinology·T F Sadow, R T Rubin
Dec 21, 2002·Neurobiology of Aging·Scott A LynessHelena C Chui
May 1, 2012·Current Gerontology and Geriatrics Research·Jason P LockrowAnn-Charlotte E Granholm
Jul 1, 1989·Journal of Neurosurgery·M A HowardM R Mayberg
Feb 2, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michael A RappMary Sano
Nov 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C Q Mountjoy, W Bondareff
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·H Förstl, P Fischer
Aug 1, 1988·Annals of Neurology·R M ZweigD L Price

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