PMID: 842279Jan 1, 1977Paper

Number of Purkinje cells and Bergmann astrocytes in rats with CCl4--induced liver disease

Acta Neurologica Scandinavica
N H Diemer


The nuclei of Purkinje cells and Bergmann astrocytes were counted on sagittal sections from cerebellum and the length of stratum gangliosum was measured in rats with CCl4-induced liver disease, using an electronic image analyzer. After 8 weeks of CCl4-administration a reduction was found in the number of Purkinje cells, many of which showed homogenizating changes. Ten weeks after termination of the administration period the number of Purkinje cells was reduced by 12 percent. The number of Bergmann astrocytes remained significantly increased after 8 weeks of CCl4-administration (max. 20 per cent). The changes of Purkinje cell and Bergmann astrocyte density developed during the period of severe liver necrosis, whereas only minor changes were found in the ensuing period of liver "cirrhosis". In the perfusion fixed specimens, the Bergmann astrocyte nuclei increased in volume up to 65 per cent and immersion fixed brains showed typical Alzheimer type II nuclear changes. The impact of the increased plasma ammonia concentration on the astrocytes is discussed.


Feb 1, 1975·Archives of Neurology·J A Gutierrez, M D Norenberg
Feb 1, 1973·Journal of the Neurological Sciences·D M Mann, P O Yates
Jan 1, 1972·Journal of the Neurological Sciences·J B CavanaghM H Kyu
Jun 29, 1971·Experimental Brain Research·M NielsenL Klinken
Dec 1, 1970·Archives of Neurology·M Dam, M Nielsen
Oct 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·D I GrahamJ W Lawson
Jan 1, 1971·Journal of the Neurological Sciences·J B Cavanagh, M H Kyu
May 1, 1967·The Journal of Surgical Research·B S Mather
Sep 1, 1953·The American Journal of Medicine·H D LEVINE
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE


Jul 15, 1977·Acta Neuropathologica·N H DiemerL Klinken
Jun 1, 1977·Acta Neurologica Scandinavica·N H Diemer, H Laursen
Jul 7, 2009·The Medical Clinics of North America·Vinay Sundaram, Obaid S Shaikh
Sep 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·N H Diemer, K Tonnesen

Related Concepts

Toxic Effect of Carbon Tetrachloride
Cell Density
Cell Nucleus
Cerebellar Cortex Structure
Fulminant Hepatic Failure With Cerebral Edema
Liver Cirrhosis, Experimental
Liver Dysfunction

Related Feeds


Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Zeitschrift für Zellforschung und mikroskopische Anatomie
Z LodinJ Hartman
Acta Neurologica Scandinavica
A BrunJ E Olsson
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A S Basile, E A Jones
© 2021 Meta ULC. All rights reserved