PMID: 11934658Apr 6, 2002Paper

Number of years since menopause: spontaneous bone loss is dependent but response to hormone replacement therapy is independent

Bone
N H BjarnasonClaus Christiansen

Abstract

In this study we examine the influence of number of years since menopause on spontaneous bone loss and response to hormone replacement therapy (HRT) in 274 women (56.1 +/- 4.2 years) completing two placebo-controlled HRT studies of 2 or 3 year duration. Both cross sectionally and longitudinally, bone loss in untreated women was greatest closest to menopause and declined thereafter (r = 0.34, p < 0.01 for lumbar spine bone loss and r = 0.25, p < 0.05 for femoral neck bone loss when correlated with number of years since menopause), such that the loss was eliminated in the femoral neck and bone mass increased in the spine in women >10 years after menopause. In contrast, bone turnover was consistently elevated throughout postmenopause, both cross-sectionally and longitudinally. The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate. In addition, the response to various HRT regimens was independent of baseline bone mass. Whereas bone loss was significantly related to number of years since menopause, all HRT regimens applied arrested bo...Continue Reading

References

Jun 24, 1978·Lancet·R LindsayJ Garwood
Dec 1, 1983·The American Journal of Medicine·B L Riggs, L J Melton
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P RavnC Christiansen
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P RavnC Christiansen
Sep 19, 2000·American Journal of Obstetrics and Gynecology·N H BjarnasonC Christiansen
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Jun 2, 2001·The New England Journal of Medicine·K L Sauder

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Citations

Dec 13, 2003·Maturitas·Jos H H Thijssen
Jan 27, 2012·Menopause : the Journal of the North American Menopause Society·Hugh S Taylor, Kathleen Ohleth
Mar 25, 2008·Therapeutics and Clinical Risk Management·P J J Prinsloo, D J Hosking
Jun 29, 2005·Treatments in Endocrinology·Aparna MahakalaMichael Kleerekoper
Feb 10, 2010·Journal of Women's Health·Dale W StovallAnne E de Papp
Dec 6, 2008·Climacteric : the Journal of the International Menopause Society·N H BjarnasonC Christiansen
May 4, 2011·Gender Medicine·Jeffrey P Levine
Jan 13, 2005·International Journal of Cancer. Journal International Du Cancer·John R Mackey, Anil A Joy
Nov 26, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Pauliina TuomikoskiTomi S Mikkola
Dec 24, 2011·Climacteric : the Journal of the International Menopause Society·N H BjarnasonC Christiansen
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Michael R McClungUNKNOWN Early Postmenopausal Intervention Cohort Study
Mar 25, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J WuL Li

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