PMID: 7515660Mar 1, 1994Paper

Numerical chromosomal aberrations in thyroid tumors detected by double fluorescence in situ hybridization

Genes, Chromosomes & Cancer
D TaruscioD C Ward

Abstract

Double fluorescence in situ hybridization with DNA probes specific for the (peri)centromeric regions of chromosomes 3, 7, 9, 11, 12, 18, and X was performed on fresh isolated nuclei and frozen tissue sections prepared from 2 nodular hyperplasias, 2 adenomas, and 7 papillary carcinomas of the thyroid in order to detect numerical chromosomal changes. Numerical chromosomal aberrations were found in all malignant specimens examined. A consistent presence of at least two trisomies was detected in most cases, especially in the follicular variant specimens; the highest degree of trisomy was observed for chromosome 12. Isolated monosomies of moderate degree for different chromosomes were found in 1 adenoma and 2 papillary carcinomas. Severe monosomy of chromosome 9 was the only significant feature observed in the single metastatic papillary carcinoma.

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Citations

Mar 14, 2002·Head & Neck·Daniel L StolerGarth R Anderson
Jul 1, 1995·Human Genetics·J ZedeniusC Larsson
Jan 1, 1997·Virchows Archiv : an International Journal of Pathology·D TaruscioF Giangaspero
Dec 1, 1996·Endocrine·G Kontogeorgos, K Kovacs
Jan 22, 2002·Cancer Genetics and Cytogenetics·S S CortezziP R B Ribeiro
Jun 23, 2001·The American Journal of Surgical Pathology·L A EricksonR V Lloyd
May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·A GaussenC Parmentier
Aug 27, 2011·Molecular and Cellular Endocrinology·Raffaele CiampiRossella Elisei
Nov 7, 2007·International Journal of Cancer. Journal International Du Cancer·Masahiro NakashimaIchiro Sekine

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