PMID: 16532620Mar 15, 2006Paper

Numerical modeling of in vivo plate electroporation thermal dose assessment

Journal of Biomechanical Engineering
S M Becker, A V Kuznetsov

Abstract

Electroporation is an approach used to enhance the transport of large molecules to the cell cytosol in which a targeted tissue region is exposed to a series of electric pulses. The cell membrane, which normally acts as a barrier to large molecule transport into the cell interior, is temporarily destabilized due to the development of pores in the cell membrane. Consequently, agents that are ordinarily unable enter the cell are able to pass through the cell membrane. Of possible concern when exposing biological tissue to an electric field is thermal tissue damage associated with joule heating. This paper explores the thermal effects of various geometric, biological, and electroporation pulse parameters including the blood vessel presence and size, plate electrode configuration, and pulse duration and frequency. A three-dimensional transient finite volume model of in vivo parallel plate electroporation of liver tissue is used to develop a better understanding of the underlying relationships between the physical parameters involved with tissue electroporation and resulting thermal damage potential.

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Citations

Nov 9, 2007·PloS One·Bassim Al-SakereLluis M Mir
Nov 28, 2013·PloS One·Felipe MagliettiGuillermo Marshall
Jun 19, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Domoina RatovosonFranck Jourdan
Aug 3, 2007·Technology in Cancer Research & Treatment·Jon F Edd, Rafael V Davalos
Jul 30, 2010·The Journal of Membrane Biology·Paulo A GarciaRafael V Davalos
Oct 11, 2008·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·A J KnulstS Schutte

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