Numerical modelling of skin tumour tissue with temperature-dependent properties for dynamic thermography

Computers in Biology and Medicine
J IljažJ Marn

Abstract

Dynamic thermography has been clinically proven to be a valuable diagnostic technique for skin tumour detection as well as for other medical applications, and shows many advantages over static thermography. Numerical modelling of heat transfer phenomena in biological tissue during dynamic thermography can aid the technique by improving process parameters or by estimating unknown tissue parameters based on measurement data. This paper presents a new non-linear numerical model of multilayer skin tissue containing a skin tumour together with thermoregulation response of the tissue during the cooling-rewarming process of dynamic thermography. The thermoregulation response is modelled by temperature-dependent blood perfusion rate and metabolic heat generation. The aim is to describe bioheat transfer more realistically. The model is based on the Pennes bioheat equation and solved numerically using a subdomain BEM approach treating the problem as axisymmetrical. The paper includes computational tests for Clark II and Clark IV tumours, comparing the models using constant and temperature-dependent properties which showed noticeable differences and highlighted the importance of using a local thermoregulation model. Results also show the ...Continue Reading

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