Numerical rule coding in the prefrontal, premotor, and posterior parietal cortices of macaques.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniela VallentinAndreas Nieder

Abstract

Switching flexibly between behavioral goals is a hallmark of executive control and requires integration of external and internal information. We recorded single-neuron correlates of different numerical representations (sensory-, working memory-, and rule-related activity) in the dorsal premotor area (PMd), the cingulate motor areas (CMA), and the ventral intraparietal sulcus (VIP) and compared them to previous recordings in the lateral prefrontal cortex (PFC). Two monkeys were trained to encode and memorize numerosities and flexibly switch between two abstract quantitative rules based on rule cues. Almost 20% of randomly selected PFC and PMd neurons significantly represented the numerical rule in a behaviorally relevant manner, approximately twice as many as in the CMA and VIP. Rule selectivity was significantly better for PMd neurons than for PFC cells. Seemingly at the expense of rule selectivity, however, sensory- and memory-related numerosity activity was greatly diminished compared with previous delayed match-to-numerosity studies. These findings suggest the involvement of the frontal premotor areas in strategic planning such as rule following. Moreover, the results emphasize that the coding capacities of neurons in associ...Continue Reading

Citations

Oct 12, 2012·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Andreas Nieder
Jul 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andreas Nieder
Dec 19, 2013·Journal of Cognitive Neuroscience·Anne-Kathrin Eiselt, Andreas Nieder
Jan 1, 2014·Trends in Cognitive Sciences·Aldo GenovesioRichard E Passingham
Dec 10, 2013·The European Journal of Neuroscience·Maria Moskaleva, Andreas Nieder
Aug 4, 2015·Frontiers in Psychology·Shingo TanakaMasamichi Sakagami
Apr 27, 2016·Current Biology : CB·Araceli Ramirez-CardenasAndreas Nieder
May 7, 2016·Nature Reviews. Neuroscience·Andreas Nieder
Apr 14, 2016·Annual Review of Neuroscience·David J Freedman, John A Assad
Oct 26, 2016·Trends in Cognitive Sciences·Andreas Nieder
Nov 29, 2013·Nature Communications·Lena Veit, Andreas Nieder
Jun 8, 2018·Journal of Cognitive Neuroscience·Apoorva BhandariDavid Badre
Jan 3, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas Nieder
Nov 19, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas Nieder, Richard Mooney
Feb 20, 2020·Journal of Cognitive Neuroscience·Pooja Viswanathan, Andreas Nieder
Oct 19, 2017·The European Journal of Neuroscience·Pooja Viswanathan, Andreas Nieder
Nov 16, 2016·Brain and Behavior·Bihua CaoHong Li
Aug 20, 2017·Scientific Reports·Dmitry Balakhonov, Jonas Rose
Sep 16, 2020·Nature Reviews. Neuroscience·Farshad Alizadeh MansouriMark J Buckley
Mar 17, 2021·The Journal of Experimental Biology·Andreas Nieder
May 1, 2021·Trends in Cognitive Sciences·Andreas Nieder

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