Numerical simulations of flow in cerebral aneurysms: comparison of CFD results and in vivo MRI measurements

Journal of Biomechanical Engineering
Vitaliy L RayzD Saloner

Abstract

Computational fluid dynamics (CFD) methods can be used to compute the velocity field in patient-specific vascular geometries for pulsatile physiological flow. Those simulations require geometric and hemodynamic boundary values. The purpose of this study is to demonstrate that CFD models constructed from patient-specific magnetic resonance (MR) angiography and velocimetry data predict flow fields that are in good agreement with in vivo measurements and therefore can provide valuable information for clinicians. The effect of the inlet flow rate conditions on calculated velocity fields was investigated. We assessed the internal consistency of our approach by comparing CFD predictions of the in-plane velocity field to the corresponding in vivo MR velocimetry measurements. Patient-specific surface models of four basilar artery aneurysms were constructed from contrast-enhanced MR angiography data. CFD simulations were carried out in those models using patient-specific flow conditions extracted from MR velocity measurements of flow in the inlet vessels. The simulation results computed for slices through the vasculature of interest were compared with in-plane velocity measurements acquired with phase-contrast MR imaging in vivo. The se...Continue Reading

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Citations

May 26, 2010·Annals of Biomedical Engineering·Vitaliy L RayzD Saloner
Oct 22, 2011·Annals of Biomedical Engineering·Amirhossein ArzaniShawn C Shadden
Nov 29, 2012·Annals of Biomedical Engineering·Monica SigovanD Saloner
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Related Concepts

Blood Flow Velocity
Mycotic Aneurysm, Intracranial
Cerebrovascular Circulation
In Silico
Image Interpretation, Computer-Assisted
Magnetization Transfer Contrast Imaging
Aneurysm
Blood Vessel
Hemodynamics
Magnetic Resonance Imaging

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