Numerical Study of Cerebroarterial Hemodynamic Changes Following Carotid Artery Operation: A Comparison Between Multiscale Modeling and Stand-Alone Three-Dimensional Modeling

Journal of Biomechanical Engineering
Fuyou LiangShu Takagi

Abstract

Free outflow boundary conditions have been widely adopted in hemodynamic model studies, they, however, intrinsically lack the ability to account for the regulatory mechanisms of systemic hemodynamics and hence carry a risk of producing incorrect results when applied to vascular segments with multiple outlets. In the present study, we developed a multiscale model capable of incorporating global cardiovascular properties into the simulation of blood flows in local vascular segments. The multiscale model was constructed by coupling a three-dimensional (3D) model of local arterial segments with a zero-one-dimensional (0-1-D) model of the cardiovascular system. Numerical validation based on an idealized model demonstrated the ability of the multiscale model to preserve reasonable pressure/flow wave transmission among different models. The multiscale model was further calibrated with clinical data to simulate cerebroarterial hemodynamics in a patient undergoing carotid artery operation. The results showed pronounced hemodynamic changes in the cerebral circulation following the operation. Additional numerical experiments revealed that a stand-alone 3D model with free outflow conditions failed to reproduce the results obtained by the m...Continue Reading

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Citations

Apr 27, 2016·Current Opinion in Biotechnology·Jessica S Yu, Neda Bagheri
Mar 31, 2018·International Journal for Numerical Methods in Biomedical Engineering·Mahsa GhaffariAndreas A Linninger
Jun 28, 2018·International Journal for Numerical Methods in Biomedical Engineering·Xinyang GeFuyou Liang
Jul 4, 2018·International Journal for Numerical Methods in Biomedical Engineering·Hongtao YuBryan R Ludwig
Aug 13, 2020·International Journal for Numerical Methods in Biomedical Engineering·Rongliang ChenXiao-Chuan Cai
May 25, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M GonserN Ochsenbein-Kölble

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