Numerical study of in situ preconcentration for rapid and sensitive nanoparticle detection

Biomicrofluidics
Kai Yang, J Wu

Abstract

This paper presents a numerical study of a preconcentrator design that can effectively increase the binding rate at the sensor in a real time manner. The particle enrichment is realized by the ac electrothermal (ACET) effect, which induces fluid movement to carry nanoparticles toward the sensor. The ACET is the only electrical method to manipulate a biological sample of medium to high ionic strength (>0.1 Sm, e.g., 0.06x phosphate buffered saline). The preconcentrator consists of a pair of electrodes striding over the sensor, simple to implement as it is electrically controlled. This preconcentrator design is compatible and can be readily integrated with many types of micro- to nanosensors. By applying an ac signal over the electrodes, local vortices will generate a large velocity perpendicular to the reaction surface, which enhances transport of analytes toward the sensor. Our simulation shows that the binding rate at the sensor surface is greatly enhanced. Our study also shows that the collection of analytes will be affected by various parameters such as channel height, inlet velocity, and sensor size, and our results will provide guidance in optimization of the preconcentrator design.

References

Feb 15, 2000·Journal of Mathematical Biology·D A EdwardsD S Cohen
Dec 2, 2004·Analytical Chemistry·Pak Kin WongChih-Ming Ho
Apr 14, 2005·Nano Letters·Paul E Sheehan, Lloyd J Whitman
Jun 29, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ketan H BhattOrlin D Velev
Nov 16, 2005·Lab on a Chip·Marin SigurdsonCarl D Meinhart
Oct 26, 2007·Lab on a Chip·Hope C FeldmanCarl D Meinhart
Apr 9, 2008·Nature Biotechnology·Todd M SquiresScott R Manalis

Citations

Jan 10, 2014·Biomicrofluidics·Wang ZhaoGuodong Sui
Sep 27, 2014·Electrophoresis·Shanshan LiHongyuan Jiang
Mar 30, 2018·Annual Review of Analytical Chemistry·David GasperinoBernhard H Weigl
Mar 1, 2017·Colin DaltonAlinaghi Salari

Methods Mentioned

BETA
biosensor

Related Concepts

Ion Channel
Inorganic phosphate
Deoxynivalenol
Surface
Local
In Situ
Size
Particle
Simulation
Binding (Molecular Function)

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