Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function

Diabetes
I DahlmanPeter Arner

Abstract

Central fat accumulation is a strong risk factor for type 2 diabetes. Genome-wide association studies have identified numerous loci associated with body fat distribution. The objectives of the current study are to examine whether genes in genetic loci linked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue function. We show, in a cohort of 114 women, that almost half of the 96 genes in these loci are indeed associated with abdominal subcutaneous adipose tissue parameters. Thus, adipose mRNA expression of the genes is strongly related to adipose morphology, catecholamine-induced lipid mobilization (lipolysis), or insulin-stimulated lipid synthesis in adipocytes (lipogenesis). In conclusion, the genetic influence on body fat distribution could be mediated via several specific alterations in adipose tissue morphology and function, which in turn may influence the development of type 2 diabetes.

References

Jan 1, 1997·Clinical Science·J B Prins, S O'Rahilly
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Oct 23, 2009·Diabetes·Erik ArnerPeter Arner
Apr 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Peter ArnerMikael Rydén
May 15, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D SchleinitzP Kovacs
Mar 19, 2014·Diabetologia·Dorit SchleinitzPeter Kovacs
Apr 16, 2014·Trends in Endocrinology and Metabolism : TEM·Peter Arner, Dominique Langin
Feb 13, 2015·Nature·Dmitry ShunginKaren L Mohlke

❮ Previous
Next ❯

Citations

Apr 23, 2016·PloS One·Rona J StrawbridgeIngrid Dahlman
Oct 12, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jiazhen TangWeiqin Chen
Jun 18, 2017·The EMBO Journal·Alexandros VegiopoulosStephan Herzig
Jun 13, 2019·G3 : Genes - Genomes - Genetics·Maren E CannonKaren L Mohlke
Mar 9, 2017·American Journal of Physiology. Endocrinology and Metabolism·Ingrid DahlmanAgné Kulyté
Aug 12, 2018·Journal of Lipid Research·Aaron P FrankDeborah J Clegg
Nov 10, 2017·The Journal of Clinical Endocrinology and Metabolism·Paul PetrusMikael Rydén
Aug 2, 2018·Physiological Reviews·Ann HammarstedtUlf Smith
Feb 23, 2017·Frontiers in Endocrinology·Samantha Laber, Roger D Cox
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Sara L PulitCecilia M Lindgren
Jun 6, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Kelvin H M KwokIngrid Dahlman
May 1, 2018·Nursing Ethics·Audrey TluczekMartha Turner
May 1, 2021·Diagnostics·Mario Ollero, Dil Sahali
Aug 17, 2021·Frontiers in Genetics·Adeline DivouxSteven R Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Seikagaku. The Journal of Japanese Biochemical Society
H Okuda
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Ying-Kui YangCarroll M Harmon
© 2022 Meta ULC. All rights reserved