PMID: 9421088Jul 1, 1997Paper

Numerous vessels detected by CD34 in the villous stroma of complete hydatidiform moles

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
S QiaoN Nakashima

Abstract

It has been considered that the villous stroma of complete hydatidiform moles (CHMs) is usually avascular. Vessels would normally form if embryogenesis had occurred. But judging by the structural maturity of molar villi, it was suspected that they must contain a considerable number of blood vessels and an attempt was made to demonstrate their presence. It has been shown previously that the vascular endothelial cell markers factor VIII related antigen (FVIII-RAg), Ulex europaeus 1 agglutinin (UEA-1) and CD31 were of no use in demonstrating the vessels in molar villi. A monoclonal antibody, QBEND/10, raised against the CD34 antigen in human endothelial cell membranes and hemopoietic progenitor cells, was selected to test its use as a marker of villous vascular endothelial cells in CHMs. On immunohistochemical analysis, numerous blood vessels were found using CD34 antibody in the stroma of CHMs, and the numbers corresponded to those found in normal villi of gestational age 8-12 weeks. Moreover, the luminal free surface of all vascular endothelial cells was so specifically delineated that it permitted the identification of vessels not apparent on hematoxylin- and eosin-stained sections; other stromal cells and trophoblast were not ...Continue Reading

Citations

Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marek ZygmuntOlin D Liang
Jul 25, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K YoshidaO Tomomitsu
Jan 1, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jimmy Espinoza
Mar 17, 2010·American Journal of Obstetrics and Gynecology·Jimmy EspinozaStanley M Berry

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