NuMoM2b Sleep-Disordered Breathing study: objectives and methods

American Journal of Obstetrics and Gynecology
Francesca L FaccoPhyllis C Zee

Abstract

The objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk factor for adverse pregnancy outcomes. NuMoM2b is a prospective cohort study of 10,037 nulliparous women with singleton gestations that was conducted across 8 sites with a central Data Coordinating and Analysis Center. The Sleep Disordered Breathing substudy recruited 3702 women from the cohort to undergo objective, overnight in-home assessments of sleep disordered breathing. A standardized level 3 home sleep test was performed between 6(0)-15(0) weeks' gestation (visit 1) and again between 22(0)-31(0) weeks' gestation (visit 3). Scoring of tests was conducted by a central Sleep Reading Center. Participants and their health care providers were notified if test results met "urgent referral" criteria that were based on threshold levels of apnea hypopnea indices, oxygen saturation levels, or electrocardiogram abnormalities but were not notified of test results otherwise. The primary pregnancy outcomes to be analyzed in relation to maternal sleep disordered breathing are preeclampsia, gestational hypertension, gestational...Continue Reading

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Citations

Jan 31, 2016·American Journal of Epidemiology·David M HaasUNKNOWN National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network
Jul 18, 2017·American Journal of Obstetrics and Gynecology·Samuel ParryUNKNOWN Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be
Sep 11, 2019·Obstetrics and Gynecology·Robert M SilverUNKNOWN Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (NuMoM2b) Study
May 28, 2019·Sleep·James P KileyGary H Gibbons
Oct 19, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Yu Sun BinPeter A Cistulli
Jul 13, 2018·The International Journal of Behavioral Nutrition and Physical Activity·Janet M CatovUNKNOWN NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Network
Jul 17, 2020·Current Hypertension Reports·Gabriela Querejeta RocaNatalie A Bello
Oct 5, 2016·BioMed Research International·Alison WimmsJeffery Armitstead
Dec 22, 2020·American Journal of Obstetrics & Gynecology MFM·Francesca L FaccoUNKNOWN NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks
Mar 24, 2021·Sleep Medicine·Marquis HawkinsUNKNOWN NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks

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