Numtogenesis as a mechanism for development of cancer

Seminars in Cancer Biology
Keshav K SinghHemant K Tiwari

Abstract

Transfer of genetic material from cytoplasmic organelles to the nucleus, an ongoing process, has implications in evolution, aging, and human pathologies such as cancer. The transferred mitochondrial DNA (mtDNA) fragments in the nuclear genome are called nuclear mtDNA or NUMTs. We have named the process numtogenesis, defining the term as the transfer of mtDNA into the nuclear genome, or, less specifically, the transfer of mitochondria or mitochondrial components into the nucleus. There is increasing evidence of the involvement of NUMTs in human biology and pathology. Although information pertaining to NUMTs and numtogenesis is sparse, the role of this aspect of mitochondrial biology to human cancers is apparent. In this review, we present available knowledge about the origin and mechanisms of numtogenesis, with special emphasis on the role of NUMTs in human malignancies. We describe studies undertaken in our laboratory and in others and discuss the influence of NUMTs in tumor initiation and progression and in survival of cancer patients. We describe suppressors of numtogenesis and evolutionary conserved mechanisms underlying numtogenesis in cancer. An understanding the emerging field of numtogenesis should allow comprehension of...Continue Reading

Citations

May 13, 2020·Genome Génome / Conseil National De Recherches Canada·María J Puertas, Mónica González-Sánchez
Jan 31, 2020·Human Genetics·Joseph C ReynoldsChanghan Lee
Sep 10, 2020·Frontiers in Physiology·Anna GiovanettiStefano Rufini
Nov 30, 2018·Biochemistry. Biokhimii︠a︡·T F Kovalenko, L I Patrushev
Mar 26, 2021·Molecular Genetics & Genomic Medicine·Xuejing LiYingshuo Wang
May 29, 2021·Nature Reviews. Cancer·Piotr K KopinskiDouglas C Wallace

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Molekuliarnaia biologiia
A I Gaziev, G O Shaĭkhaev
Mitochondrion
Nicolai Balle LarsenLene Juel Rasmussen
Molecular Phylogenetics and Evolution
Matthias BerntPeter F Stadler
© 2022 Meta ULC. All rights reserved