Nupr1: the Swiss-knife of cancer

Journal of Cellular Physiology
Carla CanoJuan L Iovanna

Abstract

Nupr1 is a small, highly basic and loosely folded multifunctional protein whose expression is induced by several stresses. Its relation to cancer was first suggested by its overexpression in several human malignancies and the association of its expression with breast cancer metastasis. Accordingly, Nupr1 is structurally related to the high-mobility group (HMG) of transcriptional regulators, which play a key role in the stress response and in cancer progression. Nupr1 interacts with numerous partners to regulate cell cycle, programmed cell death, autophagy, chromatin accessibility, and transcription, and its expression is required for regulation of TGFβ activity. Pleiotropic functions accomplished by Nupr1 depend on its molecular partners, its location into the cell, its expression level and on the cell-type. Nupr1 might be a new drug-targetable protein whose blockade would prevent cancer progression and metastasis development.

References

Mar 27, 1999·European Journal of Biochemistry·S VasseurJ L Iovanna
Jul 15, 1999·Biochemical and Biophysical Research Communications·Y F JiangJ L Iovanna
Nov 1, 2000·The Journal of Biological Chemistry·J A EncinarJ L Iovanna
Dec 12, 2001·Development, Growth & Differentiation·T IgarashiM Asashima
Jan 31, 2002·EMBO Reports·Sophie VasseurJuan Lucio Iovanna
Feb 5, 2002·European Journal of Cell Biology·A Garcia-MonteroJ L Iovanna
Jun 18, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David TaïebSophie Vasseur
Nov 19, 2005·Journal of Cellular Biochemistry·Maria Pia ValaccoSilvia Moreno
Nov 23, 2005·Biochemical and Biophysical Research Communications·Cédric MalicetJuan L Iovanna
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valentin GirouxJuan L Iovanna
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cédric MalicetJuan L Iovanna
Apr 18, 2006·Cancer Cell·Arkaitz CarracedoGuillermo Velasco
Jul 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Günter PäthJochen Seufert
Sep 19, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K KallwellisR Walther
Oct 4, 2006·International Journal of Molecular Medicine·Wen G JiangOystein Fodstad
Aug 4, 2009·Journal of Cellular Physiology·Meritxell GironellaJuan Lucio Iovanna
Aug 5, 2009·Autophagy·María SalazarGuillermo Velasco

❮ Previous
Next ❯

Citations

Mar 29, 2011·Human Molecular Genetics·Michael A GrassiDan L Nicolae
Feb 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yingjun SuAnn Richmond
Nov 10, 2013·PloS One·David Aguado-LleraJuan L Iovanna
Mar 8, 2014·World Journal of Gastroenterology : WJG·Julian SwierczynskiTomasz Sledzinski
Aug 27, 2011·Biochemical and Biophysical Research Communications·J AverousP Fafournoux
Jun 24, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Claudia LuckertAlfonso Lampen
Mar 13, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Michael R DonaldsonKristina M Miller
Aug 23, 2016·The Journal of Clinical Investigation·Adriano MaidaAdam J Rose
Dec 6, 2014·Archives of Biochemistry and Biophysics·Sebastian WeisAlbrecht Hoffmeister
Apr 6, 2017·Scientific Reports·Krithika LingappanBhagavatula Moorthy
Apr 27, 2012·Anatomy & Cell Biology·Ki-Sun KimSae-Ock Oh
Jan 25, 2019·Bioscience Reports·Li Tan, Raghunatha R Yammani
Mar 29, 2019·The Journal of Clinical Investigation·Patricia Santofimia-CastañoJuan Iovanna
Jul 26, 2019·PLoS Neglected Tropical Diseases·Priscila R AndradeRobert L Modlin
May 9, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Makoto ShirakiAkiko Kukita
Jul 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Patricia Santofimia-CastañoJosé L Neira
Mar 4, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li TanRaghunatha R Yammani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.