Abstract
The interaction between macrophages and oxLDL plays a crucial role in the initiation and progression of atherosclerosis. As a key initiator in a number of plaque promoting processes, oxLDL induces variable effects such as cell apoptosis or proliferation. Orphan nuclear receptor Nur77 is potently induced in macrophages by diverse stimuli, suggesting that it is of importance in vascular inflammation resulting in atherosclerosis, but whether Nur77 induction is detrimental or protective is unclear. In our study, we explore the role of Nur77 in the regulation of oxLDL-induced macrophage apoptosis and the signaling pathways that are involved. We found that oxLDL induced Nur77 expression in a dose and time dependent fashion, and cell viability was decreased in parallel. To determine whether Nur77 induction contributes to the loss of cell viability or is a protective mechanism, the effect of Nur77 overexpression was examined. Importantly, Nur77 overexpression inhibited the oxLDL-induced decrease of cell viability, inhibited the production of apoptotic bodies and restored DNA synthesis following oxLDL exposure. Furthermore, we found that Nur77 induction is mediated through the p38 MAPK signaling pathway. After pretreatment with SB203580...Continue Reading
References
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg
Jul 22, 1998·Molecular and Cellular Biology·Y LiX K Zhang
Jan 12, 2000·Experimental & Molecular Medicine·C Y Han, Y K Pak
Dec 10, 2002·Science·Gary L Johnson, Razvan Lapadat
May 15, 2004·Cell Death and Differentiation·I Tabas
Dec 9, 2004·Current Drug Targets. Inflammation and Allergy·Hui-Chen HsuJohn D Mountz
Jan 25, 2005·Cardiovascular Research·José Martínez-González, Lina Badimon
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jun 21, 2005·The Journal of Biological Chemistry·Liming PeiPeter Tontonoz
May 26, 2006·The American Journal of Pathology·Vivian de WaardCarlie J M de Vries
Nov 7, 2006·Cardiovascular Research·Dorien M SchrijversWim Martinet
Apr 10, 2007·Trends in Cardiovascular Medicine·Peter I BontaCarlie J M de Vries
Sep 22, 2007·Current Opinion in Lipidology·Thijs W H PolsCarlie J M de Vries
Jan 15, 2008·Atherosclerosis·Ling-Hong ShenBen He
Feb 20, 2008·Atherosclerosis·Natalia ErmakStéphanie Vicca
Apr 30, 2008·The Journal of Experimental Medicine·Jennifer Thompson, Astar Winoto
Jan 21, 2009·Circulation·Takashi NomiyamaDennis Bruemmer
Jan 23, 2009·The Journal of Nutritional Biochemistry·Paola PalozzaFranco O Ranelletti
Apr 13, 2010·Journal of Molecular and Cellular Cardiology·Qin ShaoBen He
Apr 16, 2010·Molecular Endocrinology·Michael A Pearen, George E O Muscat
Mar 25, 2011·Biochemical Society Transactions·Jason P McMorrow, Evelyn P Murphy
Nov 15, 2011·Oncogene·S-O LeeS Safe
Dec 4, 2013·Molecular Endocrinology·Stephen SafeSyng-Ook Lee
Citations
Nov 28, 2016·Journal of Neurochemistry·Tian-Ya LiuXue-Chu Zhen
Feb 23, 2018·Assay and Drug Development Technologies·Manman SuTianmin Xu
Jan 10, 2018·Frontiers in Molecular Neuroscience·Michael P GreenwoodDavid Murphy
Apr 2, 2020·International Journal of Molecular Sciences·Jicheng Yue, José M López
May 4, 2017·Oncotarget·Xiupeng ZhangEnhua Wang
Jul 18, 2018·Journal of Diabetes Research·Lei ZhangYanzhang Li
Feb 2, 2021·PeerJ·Yueqi LiHao Liang
Jan 23, 2021·Gene·Zhi Hou GuoJun Sheng Lin
Nov 14, 2020·Scientific Reports·Zhilin WuDanying Liao
May 28, 2021·Biochemical Pharmacology·Qiong-Ying HuJie Liu
Jul 31, 2021·Journal of the American Heart Association·Hengyuan ZhangJun Pu
May 3, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing LuLiwei Sun