Nur77 inhibits oxLDL induced apoptosis of macrophages via the p38 MAPK signaling pathway

Biochemical and Biophysical Research Communications
Qin ShaoBen He

Abstract

The interaction between macrophages and oxLDL plays a crucial role in the initiation and progression of atherosclerosis. As a key initiator in a number of plaque promoting processes, oxLDL induces variable effects such as cell apoptosis or proliferation. Orphan nuclear receptor Nur77 is potently induced in macrophages by diverse stimuli, suggesting that it is of importance in vascular inflammation resulting in atherosclerosis, but whether Nur77 induction is detrimental or protective is unclear. In our study, we explore the role of Nur77 in the regulation of oxLDL-induced macrophage apoptosis and the signaling pathways that are involved. We found that oxLDL induced Nur77 expression in a dose and time dependent fashion, and cell viability was decreased in parallel. To determine whether Nur77 induction contributes to the loss of cell viability or is a protective mechanism, the effect of Nur77 overexpression was examined. Importantly, Nur77 overexpression inhibited the oxLDL-induced decrease of cell viability, inhibited the production of apoptotic bodies and restored DNA synthesis following oxLDL exposure. Furthermore, we found that Nur77 induction is mediated through the p38 MAPK signaling pathway. After pretreatment with SB203580...Continue Reading

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Citations

Feb 23, 2018·Assay and Drug Development Technologies·Manman SuTianmin Xu
Jan 10, 2018·Frontiers in Molecular Neuroscience·Michael P GreenwoodDavid Murphy
Apr 2, 2020·International Journal of Molecular Sciences·Jicheng Yue, José M López
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Jul 18, 2018·Journal of Diabetes Research·Lei ZhangYanzhang Li

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