PMID: 22560073DOI: 10.1016/j.stem.2012.04.011May 9, 2012Paper
NuRD and pluripotency: a complex balancing act.
Cell Stem Cell
Guang Hu, Paul A Wade
Abstract
Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.
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