Nurr1 mutational screen in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Eng-King TanYi Zhao

Abstract

We performed sequence analysis of all the exons and exon-intron boundaries in familial and young-onset Parkinson's disease (PD) in an Asian cohort. None of the patients carried any pathogenic mutations in the Nurr1 gene. We demonstrated a 5 to 10% prevalence of the intron 7 +33 C-->T variant among Malay and Indian PD and healthy controls, suggesting that this variant, which was previously described only in 1 Chinese patient, was not a silent mutation but a common polymorphic variant in some ethnic races.

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Citations

Feb 9, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H LiuW Le
Oct 12, 2013·Journal of Molecular Cell Biology·Daniel C Berwick, Kirsten Harvey
Mar 11, 2016·BMC Medical Genomics·Maykel Cruz-MonteagudoEduardo Tejera
Mar 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·David A GrimesDennis E Bulman
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May 9, 2008·Neuroreport·Yan Xiang Yang, David S Latchman
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Aug 15, 2020·Molecular Genetics & Genomic Medicine·Ran ZhengBao-Rong Zhang

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