Nurr1 reduction influences the onset of chronic EAE in mice

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Francesca MontaroloAntonio Bertolotto

Abstract

Nurr1 plays anti-inflammatory functions in astrocytes/microglia. Gene expression analysis reveals Nurr1 down-regulation in PBMCs of MS patients that negatively correlates with disease aggressiveness. This study assesses the consequences of Nurr1 reduction in a MS model represented by EAE. EAE was induced in heterozygous Nurr1 knockout mice. Clinical course was evaluated during pre-symptomatic, acute, and chronic phases. Neurohistopathological state was analyzed in spinal cord. Nurr1 defect induces early EAE onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE.

References

May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·O Saucedo-CardenasO M Conneely
Jan 22, 2013·Nature Immunology·Takashi SekiyaAkihiko Yoshimura

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Citations

Dec 20, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F MontaroloA Bertolotto
Mar 20, 2020·Disease Models & Mechanisms·Valeria ValsecchiAlessandro Vercelli
Aug 18, 2016·Neuroreport·Scott W LallierLynette K Rogers
Oct 3, 2019·International Journal of Molecular Sciences·Francesca MontaroloAntonio Bertolotto
Jul 13, 2021·Journal of Medicinal Chemistry·Sabine WillemsDaniel Merk
Aug 8, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Chiara FurlanEliana Gianolio
Oct 12, 2021·Journal of Medicinal Chemistry·Daniel ZaienneDaniel Merk

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