Nurse-like cells in rheumatoid arthritis: Formation of survival niches cooperating between the cell types

Modern Rheumatology
T OchiPeter E Lipsky

Abstract

Nurse-like cells (NLCs) established from bone marrow and synovial tissue of rheumatoid arthritis (RA) patients were found to promote maturation and differentiation of B lineage cells as well as T cells. In co-culture of RA-NLCs and B cells, tight physical interactions (pseudoemperipolesis) developed, which resulted in activation of both cell types. RA-NLCs also supported myeloid cell maturation, promoting their differentiation into tartrate-resistant acid phosphatase-positive mononuclear cells, which are precursor cells of osteoclasts. In RA synovial tissue, the characteristic dendritic-shaped cells (the DCs) were electron microscopically found to form direct physical interactions with adjacent plasma cells (PCs) suspecting to be pseudoemperipolesis. The numbers of PCs accumulating in various areas tended to correlate with the numbers of the DCs, which appeared to have RA-NLC functions forming survival niches for PCs. Immunohistochemical staining analysis indicated that CD14+ cells including the DCs formed survival niches for CD138+ PCs by RA-NLC functions. Quantitative dual immunofluorescence staining studies of these areas indicated that the majority of CD14+ cells were of myeloid lineage. These survival niches promoted by RA...Continue Reading

References

Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K HayashidaP E Lipsky
Feb 24, 2006·Nature Reviews. Immunology·Takashi Nagasawa
Feb 18, 2011·Operative Orthopädie und Traumatologie·D Köhler, T Pohlemann
Jun 2, 2016·Acta histochemica·Miroslava JuríkováIvan Varga

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Citations

Apr 27, 2019·Frontiers in Immunology·Laleh KhodadadiFalk Hiepe

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