Nut consumption and incidence of cardiovascular diseases and cardiovascular disease mortality: a meta-analysis of prospective cohort studies

Nutrition Reviews
Nerea Becerra-TomásJordi Salas-Salvadó

Abstract

Previous meta-analyses evaluating the association between nut consumption and the risk of cardiovascular disease (CVD) had substantial methodological limitations and lacked recently published large prospective studies; hence, making an updated meta-analysis highly desirable. To update the clinical guidelines for nutrition therapy in relation to the European Association for the Study of Diabetes (EASD), a systematic review and meta-analysis of prospective studies was conducted using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to summarize the evidence of the association between total nuts, specific types of nuts, and the incidence of, and mortality from, CVD outcomes. Relevant articles were identified by searching the PubMed and Cochrane databases. Two independent researchers screened the articles to identify those that met the inclusion criteria. The inverse variance method with fixed-effect or random-effects models was used to pool data across studies (expressed as risk ratio [RR] and 95% confidence interval [CI]). Heterogeneity was tested and quantified using the Cochrane Q test and I2-statistic, respectively. The GRADE system was used to assess the quality of the evidence. Nineteen ...Continue Reading

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Jan 17, 2020·Metabolites·Camila WeschenfelderAline Marcadenti
Dec 11, 2019·International Journal of Environmental Research and Public Health·Yoona KimPeter M Clifton
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