NUT (Nuclear Protein in Testis) Carcinoma: A Report of Two Cases With Different Histopathologic Features.

International Journal of Surgical Pathology
Rekha ReddyJaya R Asirvatham

Abstract

NUT (nuclear protein in testis) carcinoma (NC) is an aggressive carcinoma characterized by rearrangements of the NUT gene on chromosome 15q14. Histologically, it is a poorly differentiated carcinoma composed of monotonous, medium-sized, round cells with scant amphophilic or eosinophilic cytoplasm. Foci of abrupt keratinization are often seen. In this report, we compare the morphology of 2 cases of NC. The first case shows characteristic features of uniform, round epithelioid cells admixed with foci of abrupt keratinization. The second case demonstrates nests of epithelioid-polygonal cells that appear to be loosely cribriform within a mucoid stroma. Although considered rare, the actual incidence of NC may be underestimated, as it is likely that many go undiagnosed because the morphology deviates from what is typical. Our report demonstrates that NC should always be considered in any case of an undifferentiated carcinoma and should not be excluded if typical histologic and immunohistochemical features of squamous differentiation are lacking.

References

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Citations

Dec 10, 2019·BioMed Research International·Qian W HuangBei N Peng
Nov 9, 2020·World Journal of Surgical Oncology·Sebastian JoelWolfram Weschenfelder
Jan 8, 2021·Virchows Archiv : an International Journal of Pathology·Kyriakos Chatzopoulos, Jennifer M Boland
Jun 10, 2021·International Journal of Surgical Pathology·Grosse Claudia, Grosse Alexandra
Jul 24, 2021·Journal of Cutaneous Pathology·Belen Rubio GonzalezKlaus J Busam

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Methods Mentioned

BETA
X-ray
biopsy

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