Nutraceutical approach for the management of cardiovascular risk - a combination containing the probiotic Bifidobacterium longum BB536 and red yeast rice extract: results from a randomized, double-blind, placebo-controlled study

Nutrition Journal
Massimiliano RuscicaPaolo Magni

Abstract

Probiotics incorporated into dairy products have been shown to reduce total (TC) and LDL cholesterolemia (LDL-C) in subjects with moderate hypercholesterolemia. More specifically, probiotics with high biliary salt hydrolase activity, e.g. Bifidobacterium longum BB536, may decrease TC and LDL-C by lowering intestinal cholesterol reabsorption and, combined with other nutraceuticals, may be useful to manage hypercholesterolemia in subjects with low cardiovascular (CV) risk. This study was conducted to evaluate the efficacy and safety of a nutraceutical combination containing Bifidobacterium longum BB536, red yeast rice (RYR) extract (10 mg/day monacolin K), niacin, coenzyme Q10 (Lactoflorene Colesterolo®). The end-points were changes of lipid CV risk markers (LDL-C, TC, non-HDL-cholesterol (HDL-C), triglycerides (TG), apolipoprotein B (ApoB), HDL-C, apolipoprotein AI (ApoAI), lipoprotein(a) (Lp(a), proprotein convertase subtilisin/kexin type 9 (PCSK9)), and of markers of cholesterol synthesis/absorption. A 12-week randomized, parallel, double-blind, placebo-controlled study. Thirty-three subjects (18-70 years) in primary CV prevention and low CV risk (SCORE: 0-1% in 24 and 2-4% in 9 subjects; LDL-C: 130-200 mg/dL) were randomly al...Continue Reading

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Citations

Nov 11, 2019·Reviews in Endocrine & Metabolic Disorders·Marc Schoeler, Robert Caesar
May 21, 2020·Nutrients·Maria Pia AdorniNicola Ferri
Oct 13, 2020·Frontiers in Microbiology·Maria AponteMahtab Shoukat
Feb 3, 2021·International Journal of Molecular Sciences·Jinchi JiangQixiao Zhai
Jun 23, 2021·Indian Heart Journal·Dilip KumarSomnath Dey
Aug 1, 2021·Clinical Nutrition ESPEN·Kontham Kulangara VarshaKesavan Madhavan Nampoothiri

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT02689934

Software Mentioned

ViScan
SAS

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