Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1
Organisms adjust their rate of growth depending on the availability of nutrients. Thus, when environmental conditions limit nutrients, growth is slowed and is only restored after food again becomes abundant. Many aspects of the molecular mechanisms that govern this complex control system remain unknown. However, it has been shown that the insulin/IGF-1 (insulin-like growth factor 1) receptor pathway, together with the FOXO family of transcription factors, play an important role in this process. Recent studies with the fruit fly Drosophila melanogaster have provided new insights into the regulatory circuitry that controls both growth and gene expression in response to nutrient availability.
Interplay between insulin signaling, juvenile hormone, and vitellogenin regulates maternal effects on polyphenism in ants
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress.
IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback
Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster.
Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila.
Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases.
Identification of the first insulin-like peptide in the disease vector Rhodnius prolixus: Involvement in metabolic homeostasis of lipids and carbohydrates
Knockdown of a putative insulin-like peptide gene LdILP2 in Leptinotarsa decemlineata by RNA interference impairs pupation and adult emergence
Molecular characterization and functional analysis of BdFoxO gene in the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae)
The insulin signaling pathway in honey bee (Apis mellifera) caste development - differential expression of insulin-like peptides and insulin receptors in queen and worker larvae
Protein tyrosine phosphatase encoded in Cotesia plutellae bracovirus suppresses a larva-to-pupa metamorphosis of the diamondback moth, Plutella xylostella
Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila--a role for dFoxO?
Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention
Regulation of gonad development and respiratory metabolism associated with food availability and reproductive diapause in the rice bug Leptocorisa chinensis
Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila.
Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling
bantam miRNA is important for Drosophila blood cell homeostasis and a regulator of proliferation in the hematopoietic progenitor niche
The sleeping beauty: how reproductive diapause affects hormone signaling, metabolism, immune response and somatic maintenance in Drosophila melanogaster
LKB1-AMPK modulates nutrient-induced changes in the mode of division of intestinal epithelial crypt cells in mice
Transcriptomic analysis of regulatory pathways involved in female reproductive physiology of Rhodnius prolixus under different nutritional states.
Changes in FOXO and proinflammatory cytokines in the late stage of immobilized fast and slow muscle atrophy
E93 Integrates Neuroblast Intrinsic State with Developmental Time to Terminate MB Neurogenesis via Autophagy
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