Nutrient Composition and In Vitro Antioxidant Properties of Harungana madagascariensis Stembark Extracts

Journal of Medicinal Food
Bassey Sunday AntiaUwemedimo Emmanuel Udo

Abstract

The stembarks of Harungana madagascariensis were analyzed for their content of chemical constituents, antinutrients, vitamin levels, and in vitro antioxidant properties in two solvent systems. Phytochemical screening revealed higher levels of alkaloids, saponins, and flavonoids in the methanolic (MHM) extract than in the dichloromethane (DCM) extract. The methanolic extract had higher contents of minerals, vitamins, and antinutrients except K, vitamin B1, and phytic acid, respectively. Antioxidant potentials of the stembark extracts were assessed by the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, metal chelating activity, and ferric reducing power. The methanolic extract showed a better antioxidant activity (IC50=87.66±0.97 μg/mL) in the DPPH system. The metal chelating activity was higher in the methanolic extract (92.4% at 20 mg/mL), but lower than the control ethylenediaminetetraacetic acid (EDTA). The methanolic extract also showed greater ferric reducing power and was richer in phenolics (132.24±0.61 mgGAE/g) and flavonoids (259.05±2.85 mgQE/g). Antinutrient analysis of the extracts indicated low levels of phytic acid, oxalates, and hydrocyanides below the lethal doses. The LD50 (i.p. mice) of t...Continue Reading

References

Sep 1, 1989·Journal of Ethnopharmacology·R Maïkere-FaniyoF X Habiyaremye
Dec 1, 1983·Archives of Toxicology·D Lorke
Feb 1, 1994·Acta Tropica·M C GesslerM Tanner
Apr 5, 2002·Phytotherapy Research : PTR·A S OkoliP U Ebo
May 16, 2002·Journal of Agricultural and Food Chemistry·Jennifer BurnsAlan Crozier
Oct 4, 2005·Life Sciences·Marcy J Balunas, A Douglas Kinghorn
Apr 26, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·I GülçinR Elias
Dec 1, 1935·The Biochemical Journal·R A McCance, E M Widdowson
Mar 14, 2007·Journal of Natural Products·Simeon F KouamBarbara Schulz
Jan 1, 2010·Journal of Medicinal Food·Hyun-Sun LeeHyung Joo Suh
Dec 15, 2010·International Journal of Molecular Sciences·Shu-Dong WeiYi-Ming Lin
May 24, 2013·Journal of the Egyptian Society of Parasitology·Atef A El-HelaTosson A Morsy

❮ Previous
Next ❯

Citations

May 3, 2019·Oxidative Medicine and Cellular Longevity·Humberto de Carvalho Aragão NetoReinaldo Nóbrega de Almeida
Mar 13, 2021·Phytochemistry·Ya-Ping HuangZhi-Qi Yin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

© 2021 Meta ULC. All rights reserved