Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response

Mechanisms of Ageing and Development
Eugenio MocchegianiMarco Malavolta

Abstract

In this paper, we reviewed data regarding to the pivotal role played by the zinc-gene interaction in affecting some relevant cytokines (IL-6 and TNF-alpha) and heat shock proteins (Hsp70-2) in ageing, successful ageing (nonagenarians) and in some age-related diseases (atherosclerosis and infections). The polymorphisms of the genes codifying these proteins are predictive on one hand in longevity, such as IL-6 -174G/C locus, on the other hand 1267 Hsp70-2A/B or TNF-alpha -308G/A polymorphisms are associated to worsening atherosclerosis or severe infections, respectively, rather than longevity. Taking into account that longevity has a strong genetic component but, at the same time, is affected by life style and environmental factors, the analysis of these polymorphisms in association to some immune parameters (NK cell cytotoxicity) and nutritional factors (zinc) is a useful tool to unravel the role played by these genetic factors in longevity and in the appearance of age-related diseases. Indeed, these polymorphisms are associated with chronic inflammation, low zinc ion bioavailability, depressed innate immune response and high gene expression of metallothioneins, which have a limited zinc release for an optimal innate immune resp...Continue Reading

References

Mar 1, 1995·Journal of Cellular Physiology·G A Taylor, P J Blackshear
Sep 1, 1993·European Journal of Immunology·U FagioloR Paganelli
Jul 11, 1996·The New England Journal of Medicine·J C SemenzaJ L Wilhelm
Aug 1, 1996·Acta Paediatrica Japonica; Overseas Edition·R ParamananthamK H Sit
Jul 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·P J Fraker, W G Telford
Mar 28, 1998·Trends in Biochemical Sciences·J P Mackay, M Crossley
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·W Maret, B L Vallee
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter
Jan 12, 1999·Mechanisms of Ageing and Development·E MocchegianiR Giacconi
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·W MaretE H Fischer
Jun 12, 1999·Journal of the American Geriatrics Society·L FerrucciR J Havlik
Aug 5, 1999·Experimental Gerontology·B T Ashok, R Ali
Mar 17, 2000·Immunological Reviews·C BogdanA Diefenbach
May 11, 2000·European Journal of Clinical Nutrition·J A Cruz
Jun 6, 2000·Trends in Pharmacological Sciences·E MocchegianiR Giacconi
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·T J LyonsD J Eide
Aug 17, 2000·The Journal of Infectious Diseases·A S Prasad
Aug 31, 2000·Critical Care Medicine·G J TangT Y Lee
Apr 17, 2001·Current Opinion in Hematology·H BruunsgaardB K Pedersen
Aug 15, 2001·American Journal of Medical Genetics·B D MitchellA R Shuldiner
Dec 4, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R Chernoff
Mar 1, 2002·Mechanisms of Ageing and Development·Thomas B L Kirkwood
May 25, 2002·Journal of the American Geriatrics Society·Thomas PerlsAnnibale A Puca
Jun 26, 2002·European Journal of Human Genetics : EJHG·Massimiliano BonafèClaudio Franceschi
Dec 10, 2002·Mechanisms of Ageing and Development·Toshiro AigakiTakashi Matsuo
Jan 23, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stephen L Helfand, Blanka Rogina
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Sep 12, 2003·The American Journal of Medicine·Helle BruunsgaardBernard Jeune
Oct 25, 2003·Metabolism: Clinical and Experimental·Pavel Hamet, Johanne Tremblay
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daniela U SpahlKlaus-D Kröncke
Jul 13, 2004·Annals of the New York Academy of Sciences·Eugenio MocchegianiMarco Malavolta
Sep 18, 2004·The Proceedings of the Nutrition Society·Michael J Gibney, Eileen R Gibney
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Hai HuangKenneth G Manton
Dec 14, 2004·The American Journal of Medicine·Warren S BrownerSteven R Cummings

❮ Previous
Next ❯

Citations

Sep 15, 2006·Biogerontology·Sonya VastoCalogero Caruso
May 2, 2009·Journal of Clinical Immunology·Eugenio MocchegianiMarco Malavolta
Jan 10, 2012·Age·Eugenio MocchegianiAscension Marcos
Sep 18, 2009·Biological Trace Element Research·Julie Calixto LoboDenise Mafra
Oct 14, 2008·Genes & Nutrition·Eugenio Mocchegiani, Marco Malavolta
Jun 29, 2010·The Proceedings of the Nutrition Society·E MocchegianiF Lattanzio
Mar 11, 2008·Rejuvenation Research·Robertina GiacconiEugenio Mocchegiani
Apr 30, 2008·Rejuvenation Research·Eugenio Mocchegiani, UNKNOWN Zincage Consortium
Jun 28, 2006·Immunity & Ageing : I & a·Eugenio MocchegianiGraham Pawelec
Oct 2, 2007·Immunity & Ageing : I & a·Eugenio MocchegianiMarco Malavolta
Jul 5, 2008·Expert Review of Molecular Diagnostics·Rita A Trammell, Linda A Toth
Aug 20, 2014·BioMed Research International·Khalid MahmoodJamshaid Hussain
Feb 19, 2011·The Veterinary Journal·Daniela BeghelliCarlo Renieri
May 19, 2009·The Journal of Nutritional Biochemistry·Stavroula KanoniEugenio Mocchegiani
Dec 17, 2008·Mechanisms of Ageing and Development·Tahira Farooqui, Akhlaq A Farooqui
Jul 10, 2008·Ageing Research Reviews·Robertina GiacconiEugenio Mocchegiani
Jan 15, 2008·Brain Research Reviews·Sonya VastoCalogero Caruso
May 21, 2008·Proteomics·John H BeattieIn-Sook Kwun
Apr 27, 2007·Annals of the New York Academy of Sciences·Sonya VastoCalogero Caruso
Aug 6, 2016·Journal of Immunology Research·Shijin XiaXiantao Tai
Oct 25, 2017·International Journal of Molecular Sciences·Martina MaywaldLothar Rink
Sep 13, 2019·International Journal of Molecular Sciences·Li ZuoTingyang Zhou
Apr 29, 2020·International Journal of Environmental Research and Public Health·Mathuramat SeesenPornngarm Limtrakul Dejkriengkraikul
Aug 29, 2017·BioFactors·Robertina GiacconiMauro Provinciali
Jan 7, 2015·The Journal of Nutrition, Health & Aging·A MeramatR Sharif
Dec 29, 2020·Frontiers in Immunology·Banghao JianZhengqi Lu
Mar 9, 2021·Computational and Structural Biotechnology Journal·Mohammed S Razzaque
Sep 17, 2021·Scientific Reports·Leônidas de Oliveira NetoKenio Costa Lima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.