Nutrient intake and environmental enteric dysfunction among Nepalese children 9-24 months old-the MAL-ED birth cohort study

Pediatric Research
Marianne S MorsethSigrun Henjum

Abstract

Nutrient deficiencies limit the growth and turnover of intestinal mucosa, but studies assessing whether specific nutrients protect against or improve environmental enteric dysfunction (EED) are scarce. We aimed to investigate associations between nutrient intake and EED assessed by lactulose:mannitol (L:M) ratio, anti-1-antitrypsin, myeloperoxidase (MPO), and neopterin (NEO) among children 9-24 months in Bhaktapur, Nepal. Among 231 included children, nutrient intake was assessed monthly by 24 h recalls, and 3-month usual intake was estimated using Multiple Source Method. Associations between nutrient intake and L:M ratio (measured at 15 months) were assessed using multiple linear regression, while associations between nutrient intake and fecal markers (measured quarterly) were assessed using Generalized Estimating Equations (GEE) models. We found that associations between nutrient intake from complementary food and L:M ratio, alpha-1-antitrypsin (AAT), MPO and NEO were generally negative but weak. The only significant associations between nutrient intake (potassium, magnesium, phosphorous, folate, and vitamin C) and markers for intestinal inflammation were found for MPO. Negative but weak associations between nutrient intake an...Continue Reading

References

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Nov 3, 2017·Maternal & Child Nutrition·Marianne S MorsethSigrun Henjum

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Citations

Mar 6, 2021·The Proceedings of the Nutrition Society·Paul Kelly

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Methods Mentioned

BETA
ELISA

Software Mentioned

MNDA
GEE
statistical package for the social sciences ( SPSS )
ED
MAL

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