PMID: 2497237May 1, 1989Paper

Nutrient interactions with total parenteral nutrition: effect of histidine and cysteine intake on urinary zinc excretion

The Journal of Pediatrics
S H Zlotkin

Abstract

Because cysteine and histidine, two amino acids included in total parenteral nutrition regimens, bind zinc and increase its renal ultrafilterability, my objective was to quantify the effects of infusion of amino acids, including cysteine and histidine, on urinary zinc excretion. The effect of the infusion of high amounts of cysteine and no cysteine (100 mg/kg/day vs none) and of high and low amounts of histidine (165 vs. 95 mg/kg/day) on urinary zinc excretion was determined in 14 newborn infants receiving total parenteral nutrition who had similar zinc intakes (approximately 7 mumol/kg/day). After a 72-hour adaptation period, each infant's urine was collected for two 48-hour periods. Urinary zinc excretion during the high-dose histidine and cysteine infusion periods was significantly elevated compared with that during the no-cysteine and low-dose histidine periods. Therefore concurrent intakes of specific amino acids may have to be considered when zinc dosages are calculated.

References

Nov 10, 1978·JAMA : the Journal of the American Medical Association·A S PrasadP Rabbani
Jan 1, 1975·The Journal of Clinical Investigation·D RudmanW C McGarrity
May 1, 1975·The Journal of Surgical Research·J B FreemanL Denbesten
Jan 1, 1980·American Journal of Diseases of Children·E W Reimold

❮ Previous
Next ❯

Citations

Dec 1, 1991·Pflügers Archiv : European journal of physiology·B GachotP Poujeol
Jan 1, 1995·European Journal of Pediatrics·F HeinenM Brandis
Dec 1, 1995·Clinical Biochemistry·F Y Leung
Dec 1, 1995·Pharmaceutica acta Helvetiae·B HarrakiA Favier
Sep 21, 2000·Journal of Pediatric Gastroenterology and Nutrition·D Bougle
Apr 28, 2007·Seminars in Perinatology·Jacqueline J Wessel, Samuel A Kocoshis
Apr 14, 2012·Journal of Pediatric Surgery·Sathyaprasad C Burjonrappa, Malki Miller
Mar 11, 2016·The Journal of Nutrition·Janet C KingDaniel J Raiten
Aug 31, 2020·Environmental Geochemistry and Health·Felix P PhiriMartin R Broadley
Oct 2, 2020·The Journal of Nutrition·Anna E Thalacker-Mercer, Mary E Gheller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.