Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals

Journal of Molecular and Cellular Cardiology
Valerie P Tan, Shigeki Miyamoto

Abstract

The ability of adult cardiomyocytes to regenerate is limited, and irreversible loss by cell death plays a crucial role in heart diseases. Autophagy is an evolutionarily conserved cellular catabolic process through which long-lived proteins and damaged organelles are targeted for lysosomal degradation. Autophagy is important in cardiac homeostasis and can serve as a protective mechanism by providing an energy source, especially in the face of sustained starvation. Cellular metabolism is closely associated with cell survival, and recent evidence suggests that metabolic and autophagic signaling pathways exhibit a high degree of crosstalk and are functionally interdependent. In this review, we discuss recent progress in our understanding of regulation of autophagy and its crosstalk with metabolic signaling, with a focus on the nutrient-sensing mTOR complex 1 (mTORC1) pathway.

Citations

Feb 6, 2018·Current Opinion in Critical Care·Martin D RosenthalFrederick A Moore
Sep 2, 2017·Journal of Biomedical Science·Yuling ZhouCraig S McLachlan
Dec 14, 2018·Genome Research·Caroline EsnaultHenry L Levin
Sep 14, 2017·Journal of Inherited Metabolic Disease·Adrien BigotFrançois Maillot
May 3, 2019·Cell Communication and Signaling : CCS·Carlo FolloCiro Isidoro
Nov 11, 2017·Cell Death and Differentiation·Lei SunXiaoqiang Yao
May 16, 2020·Journal of Clinical Medicine·Anna PiccaEmanuele Marzetti
Apr 1, 2017·Nature Reviews. Cardiology·Lea M D DelbridgeRoberta A Gottlieb
Jun 20, 2017·Frontiers in Aging Neuroscience·Mai A ShafeiMyra E Conway
Aug 7, 2017·Metabolomics : Official Journal of the Metabolomic Society·Kayoko YoshidaYusuke Tanigawara
Jul 26, 2018·Nature Reviews. Cardiology·Anna PiccaChristiaan Leeuwenburgh
Sep 7, 2018·European Journal of Clinical Nutrition·Daniel Tomé
Jan 30, 2019·Cell Death and Differentiation·Shigeki Miyamoto
May 27, 2017·The Biochemical Journal·Stefan Bröer, Angelika Bröer
Sep 8, 2019·Molecular Cell·Florian BeaumatinKevin M Ryan
Jan 15, 2021·Biotechnology and Applied Biochemistry·Lakhan Kma, Taranga Jyoti Baruah
Feb 16, 2021·Stem Cell Reviews and Reports·Hélia FernandesEugénia Carvalho
Feb 23, 2021·Molecular Genetics and Metabolism Reports·Jun KidoKimitoshi Nakamura
Oct 15, 2020·The Proceedings of the Nutrition Society·Daniel ToméDalila Azzout-Marniche
Jul 9, 2021·Frontiers in Molecular Biosciences·Carolina Rodríguez-SaavedraSobeida Sánchez-Nieto
Jul 29, 2021·Nature Communications·Sofía CabezudoCatalina Ribas
Aug 7, 2021·Experimental Gerontology·Anna PiccaEmanuele Marzetti
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xuefeng ZhangYong Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms