Nutrient-specific effects in the coordination of cell growth with cell division in continuous cultures of Saccharomyces cerevisiae

Archives of Microbiology
Jinbai GuoMichael Polymenis

Abstract

Cell cycle progression of Saccharomyces cerevisiae cells was monitored in continuous cultures limited for glucose or nitrogen. The G1 cell cycle phase, before initiation of DNA replication, did not exclusively expand when growth rate decreased. Especially during nitrogen limitation, non-G1 phases expanded almost as much as G1. In addition, cell size remained constant as a function of growth rate. These results contrast with current views that growth requirements are met before initiation of DNA replication, and suggest that distinct nutrient limitations differentially impinge on cell cycle progression.

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Citations

Oct 26, 2007·Molecular Biology of the Cell·Matthew J BrauerDavid Botstein
Dec 14, 2012·Cell Division·Huzefa DungrawalaBrandt L Schneider
Apr 12, 2008·PLoS Genetics·Heidi M BlankMichael Polymenis
May 4, 2005·Yeast
Aug 25, 2017·Nature Microbiology·Kyle Mohler, Michael Ibba
Feb 17, 2007·FEMS Yeast Research·Yo KikuchiYoshikazu Ohya

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