Nutrient specific feeding and endocrine effects of jejunal infusions.

Obesity
Megan J DaileyTimothy H Moran

Abstract

Intestinal nutrient infusions result in variable decreases in food intake and body weight based on the nutrient type and the specific intestinal infusion site. Only intrajejunal infusions of fatty acids decrease food intake beyond the calories infused. To test whether this extra-compensatory decrease in food intake is specific to fatty acids, small volume intrajejunal infusions of glucose (Glu) and casein hydrolysate (Cas), as well as linoleic acid (LA) were administered to male Sprague-Dawley rats. Equal kilocalorie (kcal) loads of these nutrients (11.4) or vehicle were infused into the jejunum over 7 h/day for five consecutive days. Food intake was continuously monitored and body weight was measured daily. After the infusion on the final day, rats were killed and plasma collected. Intrajejunal infusions of LA and Glu, but not Cas, suppressed food intake beyond the caloric load of the infusate with no compensatory increase in food intake after the infusion period. Rats receiving LA and Glu infusions also lost significant body weight across the infusion days. Plasma glucagon-like peptide-1 (GLP-1) was increased in both the LA and Glu rats compared with control animals, with no significant change in the Cas-infused animals. Pept...Continue Reading

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Citations

Mar 29, 2012·The Proceedings of the Nutrition Society·Rojo RasoamananaDaniel Tomé
Sep 16, 2011·American Journal of Physiology. Endocrinology and Metabolism·Megan J DaileyTimothy H Moran
Mar 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Roger ReidelbergerPrasanth K Chelikani
Feb 15, 2011·Physiology & Behavior·Timothy H Moran, Megan J Dailey
May 24, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Tamara Zietek, Hannelore Daniel
Dec 18, 2013·Appetite·Yada Treesukosol, Timothy H Moran
Jan 24, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan J DaileyTimothy H Moran
Oct 19, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rizaldy C ZapataPrasanth K Chelikani
Sep 2, 2016·The Journal of Nutrition·Alexander A MoghadamMegan J Dailey

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