Nutrient-toxic element mixtures and the early postnatal gut microbiome in a United States longitudinal birth cohort.

Environment International
Hannah E LaueMargaret R Karagas

Abstract

The infant microbiome contributes to health status across the lifespan, but environmental factors affecting microbial communities are poorly understood, particularly when toxic and essential elements interact. We aimed to identify the associations between a spectrum of other early-postnatal nutrient or toxic elemental exposures measured and the infant gut microbiome. Our analysis included 179 six-week-old infants from the New Hampshire Birth Cohort Study. Eleven elements were measured in infant toenail clippings. The gut microbiome was assessed using 16S rRNA V4-V5 hypervariable region targeted sequencing. Multivariable zero-inflated logistic normal regression (MZILN) was used to model the association between element concentrations and taxon relative abundance. To explore interactive and nonlinear associations between the exposures and specific taxa we employed Bayesian Kernel Machine Regression (BKMR). Effect modification by delivery mode, feeding mode, peripartum antibiotic exposure, and infant sex was assessed with stratified models. We found a negative association between arsenic and microbial diversity in the full population that was accentuated among infants exposed to peripartum antibiotics. Arsenic, cadmium, copper, iro...Continue Reading

Citations

Sep 25, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Mark A UnderwoodCharles L Bevins
Jun 29, 2021·Frontiers in Microbiology·Sarah E RothenbergBrianna R Beechler
Jun 22, 2021·Exposure & Health·Antonio J Signes-PastorKatarzyna Kordas
Jul 31, 2021·Journal of Hazardous Materials·K B ArunAshok Pandey
Oct 31, 2021·Archives of Disease in Childhood·Laura DiamondShaun K Morris
Nov 3, 2021·Critical Reviews in Clinical Laboratory Sciences·Sarahi Jaramillo OrtizFrédéric J Tessier

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