Nutriepigenetics and cardiovascular disease

Current Opinion in Clinical Nutrition and Metabolic Care
Anastasia Z KaleaJessica L Buxton

Abstract

We present a current perspective of epigenetic alterations that can lead to cardiovascular disease (CVD) and the potential of dietary factors to counteract their actions. In addition, we discuss the challenges and opportunities of dietary treatments as epigenetic modifiers for disease prevention and therapy. Recent epigenome-wide association studies along with candidate gene approaches and functional studies in cell culture and animal models have delineated mechanisms through which nutrients, food compounds and dietary patterns may affect the epigenome. Several risk factors for CVD, including adiposity, inflammation and oxidative stress, have been associated with changes in histone acetylation, lower global DNA methylation levels and shorter telomere length. A surplus of macronutrients such as in a high-fat diet or deficiencies of specific nutrients such as folate and other B-vitamins can affect the activity of DNA methyltransferases and histone-modifying enzymes, affecting foetal growth, glucose/lipid metabolism, oxidative stress, inflammation and atherosclerosis. Bioactive compounds such as polyphenols (resveratrol, curcumin) or epigallocatechin may activate deacetylases Sirtuins (SIRTs), histone deacetylases or acetyltransfe...Continue Reading

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Citations

Mar 18, 2020·Endocrine Reviews·Alexis Diaz-VegasSergio Lavandero
Dec 16, 2019·Archives of Pharmacal Research·Jeena GuptaDhiraj Kabra
Feb 23, 2020·Frontiers in Cardiovascular Medicine·Shin-Ichi OkaJunco S Warren
Sep 24, 2019·American Journal of Lifestyle Medicine·Shivam JoshiScott E Liebman
Mar 4, 2021·Nutrients·Manuela CassottaMaurizio Battino
May 15, 2021·Clinical Science·Abdul Waheed KhanKarin A M Jandeleit-Dahm
Jun 17, 2021·Neurochemistry International·Anoumid Vaziri, Monica Dus
Jan 22, 2019·Journal of Agricultural and Food Chemistry·Nunzia D'OnofrioGiuseppe Campanile

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