Nutrigenetics and personalized nutrition: are we ready for DNA-based dietary advice?

Personalized Medicine
Keith A Grimaldi

Abstract

Common genetic variation affects individual nutrient requirements and the use of DNA-based dietary advice, derived from nutrigenetics, has been growing. The growth is about to accelerate as the cost of genotyping continues to fall and research results from major nutrigenetics projects are published. There is still some skepticism; some barriers remain including some commercial tests, which make exaggerated, incorrect claims. There is a need for more public resources dedicated to unbiased, objective review and dissemination of nutrigenetics information; however, nutrigenetics evidence should be assessed in the context of standard nutritional evidence and should not require higher standards. This article argues that we are ready for some DNA-based dietary advice in general nutrition and it can be beneficial. Examples of the scientific validity and health utility of gene-diet interactions will be given and the development of guidelines for assessment and validation of benefits will be discussed.

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Citations

May 20, 2020·The Cochrane Database of Systematic Reviews·Natalie E ParksBradley C Johnston
Jan 1, 2017·Personalized Medicine·Thierry HurlimannBéatrice Godard
Apr 16, 2020·International Journal of Molecular Sciences·Marica FranzagoLiborio Stuppia
Mar 22, 2021·Journal of the Academy of Nutrition and Dietetics·Justine R HorneDavid M Mutch
May 6, 2020·Lifestyle Genomics·Yael Joffe, Heléne Herholdt

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Methods Mentioned

BETA
genotyping

Software Mentioned

Food4Me
Nutrigenetics

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