Nutrigenomic effects of edible bird's nest on insulin signaling in ovariectomized rats

Drug Design, Development and Therapy
Zhiping HouRozi Mahmud

Abstract

Estrogen deficiency alters quality of life during menopause. Hormone replacement therapy has been used to improve quality of life and prevent complications, but side effects limit its use. In this study, we evaluated the use of edible bird's nest (EBN) for prevention of cardiometabolic problems in rats with ovariectomy-induced menopause. Ovariectomized female rats were fed for 12 weeks with normal rat chow, EBN, or estrogen and compared with normal non-ovariectomized rats. Metabolic indices (insulin, estrogen, superoxide dismutase, malondialdehyde, oral glucose tolerance test, and lipid profile) were measured at the end of the experiment from serum and liver tissue homogenate, and transcriptional levels of hepatic insulin signaling genes were measured. The results showed that ovariectomy worsened metabolic indices and disrupted the normal transcriptional pattern of hepatic insulin signaling genes. EBN improved the metabolic indices and also produced transcriptional changes in hepatic insulin signaling genes that tended toward enhanced insulin sensitivity, and glucose and lipid homeostasis, even better than estrogen. The data suggest that EBN could meliorate estrogen deficiency-associated increase in risk of cardiometabolic dise...Continue Reading

Citations

Oct 20, 2020·Ecology and Evolution·Muhammad Amin OsmanNurul Izza Ab Ghani
Mar 3, 2021·Food Research International·Yuwei DaiLin Jiang
Apr 10, 2021·Frontiers in Pharmacology·Bee-Hui YeoOi-Ming Lai
Oct 1, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Kunio KawanishiPhilip L S M Gordts

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Methods Mentioned

BETA
hormone replacement therapy
enzyme-linked immunosorbent assay
Profiler
MDA

Software Mentioned

GeXP
eXpress Profiler
Statistical Package for the Social Sciences

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