Nutrition and aging skin: sugar and glycation

Clinics in Dermatology
F William Danby

Abstract

The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements.

References

Jun 1, 1992·Metabolism: Clinical and Experimental·P R OdettiR Rolandi
Jan 1, 1989·Critical Reviews in Food Science and Nutrition·J O'Brien, P A Morrissey
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·T KoschinskyH Vlassara
Mar 15, 2005·Experimental Diabesity Research·V ThirunavukkarasuC V Anuradha
Nov 11, 2005·Journal of the American Society of Nephrology : JASN·Robbert MeerwaldtAndries J Smit
May 4, 2006·Molecular Nutrition & Food Research·Kieran M TuohyJennifer M Ames
May 19, 2006·Rejuvenation Research·John D Furber
Apr 27, 2007·Annals of the New York Academy of Sciences·Ulrich BergeSuresh I S Rattan
May 15, 2007·Journal of Dermatological Science·Kazue TsukaharaTakashi Kitahara
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jaime Uribarri, Katherine R Tuttle
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael F HolickEdward Sauter
May 14, 2008·Diabetes Technology & Therapeutics·Alin StirbanDiethelm Tschoepe
Jul 5, 2008·Journal of Medicinal Food·Rebecca P DearloveJames L Hargrove
Nov 7, 2008·The British Journal of Nutrition·Megha SaraswatG Bhanuprakash Reddy
May 8, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D J MulderA J Smit
Nov 1, 1945·Archives of Dermatology and Syphilology·E URBACH, J W LENTZ

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Citations

Dec 3, 2014·Clinics in Plastic Surgery·Dallas R Buchanan, Allan E Wulc
Oct 29, 2013·Clinics in Dermatology·Zoe Diana Draelos
Sep 20, 2011·Seminars in Cutaneous Medicine and Surgery·Patricia K Farris
Apr 21, 2012·International Journal of Dermatology·Mohammad JafferanyZohra Zaidi
Mar 26, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Carlos GalzoteXuemin Wang
Mar 31, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sandeep S Saluja, Sabrina G Fabi
Apr 26, 2018·Cell Transplantation·Shoubing Zhang, Enkui Duan
Mar 28, 2020·Nutrients·Changwei CaoChangrong Ge
Oct 3, 2018·Aging and Disease·Maxime FournetAlexis Desmoulière
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Bauyrzhan UmbayevDenis Bulanin
Oct 30, 2020·Evolutionary Psychology : an International Journal of Evolutionary Approaches to Psychology and Behavior·Claire BerticatMichel Raymond
Jan 14, 2021·Antioxidants·Fabrizio GuarneriSebastiano Gangemi
May 18, 2013·Physical Review Letters·Yuanming LiuJiangyu Li
Jun 3, 2021·International Journal of Molecular Sciences·Dai MiyazakiSatoru Yamagami
Nov 4, 2021·Journal of the Academy of Nutrition and Dietetics·Vivien W FamRobert M Hackman

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