Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness

BMJ Open
Daren K HeylandRenee Stapleton

Abstract

Survivors of critical illness often experience significant morbidities, including muscle weakness and impairments in physical functioning. This muscle weakness is associated with longer duration mechanical ventilation, greater hospital costs and increased postdischarge impairments in physical function, quality of life and survival. Compared with standard of care, the benefits of greater protein intake combined with structured exercise started early after the onset of critical illness remain uncertain. However, the combination of protein supplementation and exercise in other populations has demonstrated positive effects on strength and function. In the present study, we will evaluate the effects of a combination of early implementation of intravenous amino acid supplementation and in-bed cycle ergometry exercise versus a 'usual care' control group in patients with acute respiratory failure requiring mechanical ventilation in an intensive care unit (ICU). In this multicentre, assessor-blinded, randomised controlled trial, we will randomise 142 patients in a 1:1 ratio to usual care (which commonly consists of minimal exercise and under-achievement of guideline-recommended caloric and protein intake goals) versus a combined intrave...Continue Reading

Associated Clinical Trials

Jan 16, 2017·Daren K. Heyland

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Citations

Nov 20, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Yaseen M ArabiMusharaf Sadat
Aug 14, 2020·Critical Care : the Official Journal of the Critical Care Forum·Christian StoppeArnold S Kristof
Oct 11, 2020·Critical Care Medicine·Zudin Puthucheary, Linda Denehy
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Nov 4, 2020·American Journal of Respiratory and Critical Care Medicine·Ann M ParkerDale M Needham
Sep 28, 2020·European Journal of Radiology·Danoob DaliliAmanda Isaac
Jul 25, 2021·Critical Care : the Official Journal of the Critical Care Forum·Zheng-Yii LeeDaren K Heyland

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT01206166

Software Mentioned

SAS

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