PMID: 109187May 1, 1979

Nutrition, cancer, and intravenous hyperalimentation

E M CopelandS J Dudrick


In over 1000 cancer patients treated with intravenous hyperalimentation (IVH), tumor growth has not been identified and catheter-related sepsis has been minimal. Studies in rats demonstrated that the host benefits more than the tumor during nutritional repletion, and any stimulation of tumor growth in the rat-tumor model could be manipulated with DNA specific drugs to benefit the host. A study of 65 malnourished cancer patients undergoing oncologic therapy and treated with IVH indicated that much of the immune suppression in these patients was the result of malnutrition coincident with or secondary to oncologic treatment. Conclusions reached in this study were that nutritional repletion resulted in a return of skin test reactivity, proper wound healing in the surgical patient, and possibly an increase in response to chemotherapy. Certainly, the use of IVH allowed specific oncologic therapy to be administered to a group of malnourished patients who otherwise might not have been acceptable candidates for intensive antineoplastic therapy.


Mar 1, 1976·Journal of the National Cancer Institute·I L Cameron, W A Pavlat
Mar 1, 1977·The Journal of Surgical Research·D M OtaS J Dudrick
May 1, 1978·JPEN. Journal of Parenteral and Enteral Nutrition·D M OtaS J Dudrick
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Jan 23, 1998·Nutrition·R J Andrassy, W J Chwals
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Aug 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M F Von MeyenfeldtP B Soeters
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Dec 24, 1981·The New England Journal of Medicine
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