Nutrition disorder and immunologic parameters: study of the intestinal villi in growing rats

Nutrition
Silvina Mariela VidueirosAnabel Pallaro

Abstract

The aim of the present work was to study how a diet in which cereals were the only protein source would affect B and T lymphocytes and a cell population positive for thymus-expressed chemokine (TECK) in the intestinal villi of growing rats. Wistar rats were fed a 6.5% precooked maize protein diet for 18-20 d (M group). An age-matched control group received stock diet (C group). Body weight (grams) was determined, ponderal growth rate (grams per day per 100 g) was calculated, and intestines were removed and processed by Saint-Marie's technique. Tissue sections were studied by indirect immunofluorescence. CD5(+) T cells and the T-cell subsets TCRalphabeta(+), TCRgammadelta(+), CD4(+), CD8alpha(+), and CD8beta(+) in the lamina propria (LP) and intraepithelium, in addition to immunoglobulin A-positive B cells in the LP were determined (n cells/30 fields were read). In addition, the presence of the TECK(+) cell population was qualitatively assessed. The M versus C group showed statistically significant differences in body weight and ponderal growth rate. The number of immunoglobulin A-positive B cells in the LP and the CD5(+) T cells and CD4(+), CD8alpha(+), CD8beta(+), TCRalphabeta(+), and TCRgammadelta(+) T-cell subpopulations of ...Continue Reading

References

Jan 24, 2002·The Journal of Experimental Medicine·Edward P BowmanEugene C Butcher
Jan 24, 2002·The Journal of Experimental Medicine·Michael E Lamm, Julia M Phillips-Quagliata
May 12, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Juscilene S MenezesAna Maria C Faria

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Citations

Oct 18, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gabriella A M Ten HaveNicolaas E P Deutz

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