Nutrition-induced catch-up growth increases hypoxia inducible factor 1alpha RNA levels in the growth plate

Bone
N Even-ZoharG Gat-Yablonski

Abstract

Although catch-up growth is a well-known phenomenon, the local pathways at the epiphyseal growth plate that govern this process remain poorly understood. To study the mechanisms governing catch-up growth in the growth plate, we subjected prepubertal rats to 10 days of 40% food restriction, followed by a renewal of the regular food supply to induce catch-up growth. The animals were weighed daily, and their humeral length was measured at sacrifice. The proximal tibial epiphyseal growth plates (EGPs) were studied, and findings were compared with EGPs from animals fed ad libitum and animals under food restriction. The gene expression profile in the growth plates was examined using DNA microarrays, and the expression levels of selected genes were validated by real-time polymerase chain reaction. To localize gene expression in different growth plate zones, microdissection was used. Protein levels and localization were examined using immunohistochemistry. We showed that the expression level of 550 genes decreased during food restriction and increased during catch-up growth, starting already one day after refeeding. HIF-1alpha, as well as several of its downstream targets, was found among these genes. Immunohistochemistry showed a simi...Continue Reading

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Citations

Aug 5, 2011·American Journal of Medical Genetics. Part a·Galia Gat-YablonskiLiora Lazar
Apr 12, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Galia Gat-Yablonski, Moshe Phillip
Dec 1, 2010·Journal of Pediatric Gastroenterology and Nutrition·Rakefet PandoMoshe Phillip
Sep 24, 2015·Growth Factors·Biana ShtaifGalia Gat-Yablonski
Jan 17, 2015·Nutrients·Galia Gat-Yablonski, Moshe Phillip
May 16, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Iva BritoFernando Santos
Mar 10, 2012·The Journal of Nutritional Biochemistry·Rakefet PandoGalia Gat-Yablonski
Oct 11, 2011·Pediatric Clinics of North America·Galia Gat-YablonskiMoshe Phillip
Sep 1, 2009·Endocrinology and Metabolism Clinics of North America·Galia Gat-YablonskiMoshe Phillip
Oct 16, 2015·The Journal of Nutritional Biochemistry·Galit PintoGalia Gat-Yablonski
May 18, 2016·The British Journal of Nutrition·Majdi MasarwiGalia Gat-Yablonski
Apr 5, 2018·The Journal of Endocrinology·Majdi MasarwiGalia Gat-Yablonski
Apr 4, 2017·Hormone Research in Pædiatrics·Galia Gat-Yablonski, Francesco De Luca
Sep 25, 2014·The Journal of Endocrinology·Rakefet PandoGalia Gat-Yablonski
Dec 7, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Jasreena K Nijjar, Diane Stafford
Jan 25, 2014·Endocrinology·Rakefet PandoGalia Gat-Yablonski
Oct 24, 2009·Journal of Applied Physiology·Adi ReichEfrat Monsonego Ornan
Jul 19, 2017·Nutrients·Meytal Bar-MaiselsGalia Gat-Yablonski
Mar 21, 2019·Acta Cirúrgica Brasileira·Patrícia Madalena San Gregório GuedesJosé Batista Volpon

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