Nutrition Risk is Associated with Leukocyte Telomere Length in Middle-Aged Men and Women with at Least One Risk Factor for Cardiovascular Disease

Nutrients
Melissa Ventura MarraWilliam J Belden

Abstract

Poor diet quality has been associated with several age-related chronic conditions, but its relationship to telomere length, a biological marker of cellular aging, is unclear. The purpose of this cross-sectional study was to determine whether overall diet quality was associated with relative leukocyte telomere length (rLTL) in a sample (n = 96) of nonsmoking middle-aged adults in Appalachia with at least one risk factor for cardiovascular disease. Diet quality was assessed using the Healthy Eating Index (HEI-2015), the alternate Mediterranean diet score (aMed), and the Dietary Screening Tool (DST). Peripheral rLTL was measured by quantitative real-time polymerase chain reaction. The associations between potentially confounding sociodemographic, lifestyle and health-related factors and the first and fourth rLTL quartile groups were examined using Chi-square or Fisher's Exact tests or logistic regression. The relationships between diet quality index scores and rLTL as a continuous variable were analyzed using simple linear regression and multivariate linear models, analogous to linear covariance analyses. The rLTL ranged from 0.46 to 1.49 (mean ± SEM was 1.02 ± 0.18). Smoking history, income level, and cardiovascular health (Life'...Continue Reading

References

May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Nov 11, 2003·Nature·Fabrizio d'Adda di FagagnaStephen P Jackson
Jan 27, 2005·Annals of Family Medicine·Russell E GlasgowLarry A Green
Apr 27, 2005·Circulation·Jeffrey P GardnerAbraham Aviv
May 22, 2009·The American Journal of Clinical Nutrition·Regan L BaileyHelen Smiciklas-Wright
Jan 11, 2013·Epidemiologic Reviews·Jason L Sanders, Anne B Newman
May 7, 2013·PloS One·Virginia BoccardiGiuseppe Paolisso
Dec 25, 2013·Experimental Gerontology·Michael GardnerUNKNOWN Halcyon study team
Dec 4, 2014·BMJ : British Medical Journal·Marta Crous-BouImmaculata De Vivo
Sep 27, 2015·Obesity·Eduardo MundstockRita Mattiello
Dec 10, 2015·Nature Medicine·Bennett G ChildsJan M van Deursen
Mar 29, 2016·Geriatrics & Gerontology International·Yoshiaki TamuraHideki Ito
Apr 17, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sonia García-CalzónAmelia Marti
Aug 18, 2016·European Journal of Clinical Nutrition·N RafieM Miraghajani
Oct 28, 2016·European Journal of Nutrition·Catherine M MilteSarah A McNaughton
Jul 14, 2017·Environmental Research·Yuliana AstutiUNKNOWN PILAR Research Network
Nov 18, 2017·MMWR. Morbidity and Mortality Weekly Report·Seung Hee Lee-KwanDeb Galuska
Dec 8, 2017·Biology Letters·Sophie Reichert, Antoine Stier
Mar 15, 2018·Nutrients·Melissa Ventura MarraRegan L Bailey

❮ Previous
Next ❯

Citations

Jul 31, 2020·Advances in Nutrition·Silvia CanudasJordi Salas-Salvadó
Nov 30, 2020·The Lancet. Diabetes & Endocrinology·Feifei ChengRonald C W Ma
Mar 7, 2021·International Journal of Environmental Research and Public Health·Sze-Yen TanRachel Brown
Sep 24, 2021·Critical Reviews in Food Science and Nutrition·Bartu Eren GüneşliolZeynep Alanur Acar

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
Enzyme-Linked Immunosorbent Assay
ELISAs
PCR

Software Mentioned

JMP
REDCap ( Research Electronic Data Capture )
Seca
SAS
Seca analytics
Nutrition Data Systems for Research ( NDSR )

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.