PMID: 19123156Jan 6, 2009Paper

Nutritional AMD treatment phase I (NAT-1): feasibility of oral DHA supplementation in age-related macular degeneration

European Journal of Ophthalmology
Giuseppe QuerquesEric H Souied

Abstract

To create a pilot study in order to evaluate the feasibility of a prospective case-control study of oral supplementation with fish oil (docosahexaenoic acid [DHA]; eicosapentaenoic acid [EPA]) in a population with age-related macular degeneration (AMD). A homogeneous group of 38 patients with drusenoid pigment epithelial detachment in one eye (PED) without choroidal new vessels (CNV) was selected. A complete ophthalmologic examination, and a complete profile of fatty acids in serum (S) and in red blood cell membranes (RBCM), were recorded at day 0 and month 6. In group 1, 22 patients were orally supplemented with EPA (720 mg/day) and DHA (480 mg/day) during 6 months. In group 2, 16 patients were followed as controls. Nutritional recommendations on fish consumption were given to both groups. In group 1, after 6 months supplementation we observed a significant blood enrichment in EPA (EPA-S: 2.20 vs 0.79, p<0.0001 and EPA-RBCM: 2.24 vs 0.85, p<0.0001) and in DHA (DHA-S: 2.47 vs 1.56, p<0.0001 and DHA-RBCM: 6.47 vs 4.67, p<0.0001). No change was observed in group 2 despite nutritional recommendations. In this short followup, no evolution to CNV was noted in either of the two groups. Neither side effects nor dropouts were observed ...Continue Reading

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Citations

Sep 30, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Akira KotaniHideki Hakamata
Nov 7, 2019·Clinical Science·Eoin P BrennanPhillip Kantharidis
Dec 17, 2011·Journal of Nutrition and Metabolism·Giuseppe QuerquesEric H Souied
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Clarisse CornebiseDominique Delmas
May 11, 2021·Critical Reviews in Food Science and Nutrition·Kristin KruegerMarietta Zille

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