Nutritional and environmental factors affecting plasma ghrelin and leptin levels in rats

The Journal of Endocrinology
Keiko NakaharaN Murakami

Abstract

We examined which factors suppress the rise of ghrelin secretion under hunger in 16-h-starved rats, and compared the responses of plasma ghrelin and leptin levels to various exogenous and endogenous stimuli in intact rats. Although an acute expansion of the stomach by infusion of 6 ml air or 3 ml water in rats starved for 16 h did not change the level of plasma acyl-ghrelin 3 ml corn starch solution, corn oil, or 20% ethanol significantly decreased it. Vagotomy inhibited suppression by nutrients but not by ethanol. Chronic infusion of ethanol into the stomach for 3 weeks in free-feeding rats caused widespread injury of the stomach mucosa, and increased both plasma ghrelin levels and the number of ghrelin cells. In intact rats, low temperature did not change ghrelin levels, but increased leptin levels. On the other hand, restriction stress decreased plasma ghrelin levels, but had the reverse effect on plasma leptin levels. Although insulin decreased and 20% glucose increased plasma glucose levels, they both decreased plasma ghrelin levels. Insulin elevated plasma leptin levels, but glucose had no effect. These results indicate that 1) acyl-ghrelin secretion from the stomach under fasting condition is suppressed by nutrients but ...Continue Reading

Citations

Sep 21, 2011·The Journal of Endocrinology·Lei HuangShigong Zhu
Mar 31, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Andreas HillenbrandAnna M Wolf
Dec 29, 2013·International Journal of Endocrinology·Yusuf OzkanZekiye Catak
Nov 2, 2015·Nutrition·Natália Martins Valente Ramos BittarPatrícia Gama
Jul 23, 2015·International Journal of Genomics·Reza MahmoudiMohsen Nikseresht
Oct 25, 2017·Journal of Neurochemistry·Mohammad I Murtuza, Masako Isokawa
Mar 8, 2020·International Journal of Environmental Research and Public Health·Mohammed Saeed Al-AyedMohammed Helmy Faris Shalayel
Apr 16, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Takashi YadaKatsumi Tsukamoto

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