PMID: 26770138Jan 16, 2016Paper

Nutritional and Metabolic Biomarkers in Autism Spectrum Disorders: An Exploratory Study

Integrative Medicine
Anna E EsparhamJeanne A Drisko

Abstract

Autism spectrum disorder (ASD) is currently on the rise, now affecting approximately 1 in 68 children in the United States according to a 2010 surveillance summary from the Centers for Disease Control and Prevention (CDC). This figure is an estimated increase of 78% from the figure in 2002. The CDC suggests that more investigation is needed to understand this astounding increase in autism in such a short period. The aim of this pilot study was to determine whether a group of children with ASD exhibited similar variations in a broad array of potential correlates, including medical histories, symptoms, genetics, and multiple nutritional and metabolic biomarkers. This study was a retrospective, descriptive chart review. The study took place at the University of Kansas Medical Center (KUMC). Participants were 7 children with ASD who had sought treatment at the Integrative Medicine Clinic at the medical center. A majority of the children exhibited an elevated copper:zinc ratio and abnormal vitamin D levels. Children also demonstrated abnormal levels of the essential fatty acids: (1) α-linolenic acid (ALA)- C13:3W3, and (2) linoleic acid (LA)-C18:2W6; high levels of docosahexaenoic acid (DHA); and an elevated ω-6:ω-3 ratio. Three of ...Continue Reading

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