PMID: 9537848Apr 16, 1998Paper

Nutritional and prognostic significance of serum hypothyroxinemia in hospitalized patients with liver cirrhosis

Journal of Hepatology
L CaregaroA Gatta

Abstract

A variety of severe illnesses can induce changes in thyroid hormone metabolism, leading to findings referred to as "sick euthyroid syndrome". In several groups of patients the reduction of serum thyroxine concentration (T4), characteristic of the low-T4 variant of sick euthyroid syndrome, has been found to be a good predictor of survival. Although the pathophysiology of hormonal alterations has not yet been defined, nutritional deficits have been suggested to play a role. The study aimed to define the prognostic and nutritional significance of serum thyroxine in liver cirrhosis. Thyroid hormones and nutritional status were evaluated in a group of 75 consecutive hospitalized patients with cirrhosis, followed-up clinically for 12 months. A low-T4 variant of sick euthyroid syndrome was found in 23 of the 75 enrolled patients with cirrhosis (30.6%). Serum T4, but not serum T3, correlated with mid-arm muscle circumference (p < 0.01), an indicator of muscle protein compartment. While both serum T3 and T4 correlated directly with serum proteins and inversely with Child-Pugh score, only T4 was predictive of outcome. Patients with the low-T4 variant of sick euthyroid syndrome showed significantly lower short- and long-term survival rate...Continue Reading

References

May 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C J van NoordenJ L Touber
Feb 1, 1975·The Journal of Clinical Endocrinology and Metabolism·I J Chopra, S R Smith
Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·A G VagenakisL E Braverman
Sep 11, 1975·The Journal of Clinical Investigation·S NomuraT Shimizu
Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S W SpauldingS S Lyall
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J MüllerF W Schmidt
Nov 1, 1991·Seminars in Liver Disease·A J McCullough, A S Tavill
Jul 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MerliL Capocaccia
Feb 1, 1986·The American Journal of Clinical Nutrition·C L MendenhallR Zetterman
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C Infante-RivardJ P Villeneuve
Sep 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·M MerliL Capocaccia
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·I J ChopraD H Solomon
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J McConnonR Volpé
Jun 1, 1983·Annals of Internal Medicine·I J ChopraJ T Nicoloff
Nov 1, 1981·The American Journal of Clinical Nutrition·A R Frisancho
Jun 1, 1982·Clinical Endocrinology·E M KapteinJ T Nicoloff
Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H O Conn
Aug 1, 1994·The Clinical Investigator·M J MüllerO Selberg
Aug 1, 1994·The American Journal of Clinical Nutrition·P J Thuluvath, D R Triger
Apr 1, 1996·The American Journal of Clinical Nutrition·L CaregaroA Gatta

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Citations

Jun 12, 2001·Nutrition·F AlberinoL Caregaro
Mar 6, 2015·Wiener klinische Wochenschrift·Margit HatzlMichael Gabriel
Apr 15, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Daxian WuLanjuan Li
Feb 20, 2018·International Journal of Cancer. Journal International Du Cancer·Rui GaoWei Xu
Nov 9, 2011·Journal of Pediatric Gastroenterology and Nutrition·Wolfgang HöglerDeirdre Kelly
Oct 27, 2018·Mediators of Inflammation·Tomasz MikułaAlicja Wiercińska-Drapało

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