PMID: 9164258May 1, 1997Paper

Nutritional factors required for alcoholic liver disease in rats

The Journal of Nutrition
G A Rao, E C Larkin

Abstract

Decades ago it was suggested that nutritional factors are important in the development of alcoholic liver disease (ALD). However, several models of experimental alcoholism considered that the diets fed to animals were nutritionally adequate, complete and balanced. Therefore, a concept prevailed that the effects observed were due to alcohol per se and that they occurred despite a nutritionally adequate status in the animal. Examination of various models revealed that animals were malnourished because they ingested reduced levels of macro- and micronutrients. Furthermore, they consumed only small amounts of carbohydrate and a high level of unsaturated fat for long periods during the development of ALD. Alcoholic rats show many effects of inadequate nutritional status, such as a slow growth, depressed levels of liver glycogen and pancreatic amylase, enhanced protein degradation and circulating levels of branched-chain amino acids, and increased levels of enzymes involved in gluconeogenesis and alterations in the activities of enzymes related to the metabolism of carbohydrate as compared with controls. Chronic consumption of alcohol did not result in fatty liver, high blood alcohol concentration (BAC) or other observed effects when...Continue Reading

References

Feb 1, 1989·Alcoholism, Clinical and Experimental Research·A A NanjiS W French
Aug 1, 1988·Journal of Hepatology·C C AinleyR P Thompson
Jan 1, 1974·Journal of Medical Primatology·C S Lieber, L M DeCarli
Apr 1, 1970·The American Journal of Clinical Nutrition·C S Lieber, L M DeCarli
Apr 1, 1968·The Journal of Nutrition·E A PortaW S Hartroft
Nov 5, 1949·British Medical Journal·C H BEST, W S HARTROFT

❮ Previous
Next ❯

Citations

Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Anne M KarinchThomas C Vary
Feb 1, 2012·Drug and Chemical Toxicology·Ligia A AzzalisVirgínia B C Junqueira
Sep 21, 2000·European Journal of Clinical Investigation·J A LevineM Y Morgan
Mar 14, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Agnieszka OleszczukMichael R Schön
Jul 23, 2013·Journal of Clinical Biochemistry and Nutrition·Danijela Ristić-MedićMarija Glibetić
Oct 8, 2011·International Journal of Immunopathology and Pharmacology·Giovanni CorsettiR Rezzani
Jul 11, 2006·Current Sports Medicine Reports·Brian D Keisler, Thomas D Armsey
Dec 27, 2005·Alcohol·Dennis A ChakkalakalTerrence M Donohue
Oct 9, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sung-Hee ParkTaesun Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.