Nutritional impact of elevated calcium transport activity in carrots.

Proceedings of the National Academy of Sciences of the United States of America
Jay MorrisKendal D Hirschi

Abstract

Nutrition recommendations worldwide emphasize ingestion of plant-based diets rather than diets that rely primarily on animal products. However, this plant-based diet could limit the intake of essential nutrients such as calcium. Osteoporosis is one of the world's most prevalent nutritional disorders, and inadequate dietary calcium is a known contributor to the pathophysiology of this condition. Previously, we have modified carrots to express increased levels of a plant calcium transporter (sCAX1), and these plants contain approximately 2-fold-higher calcium content in the edible portions of the carrots. However, it was unproven whether this change would increase the total amount of bioavailable calcium. In randomized trials, we labeled these modified carrots with isotopic calcium and fed them to mice and humans to assess calcium bioavailability. In mice feeding regimes (n = 120), we measured (45)Ca incorporation into bones and determined that mice required twice the serving size of control carrots to obtain the calcium found in sCAX1 carrots. We used a dual-stable isotope method with (42)Ca-labeled carrots and i.v. (46)Ca to determine the absorption of calcium from these carrots in humans. In a cross-over study of 15 male and 1...Continue Reading

References

May 1, 1992·The American Journal of Clinical Nutrition·V Matkovic, R P Heaney
Apr 1, 1988·The American Journal of Clinical Nutrition·R P HeaneyR R Recker
Nov 1, 1987·The Journal of Nutrition·C M WeaverC A Krueger
Jan 23, 1999·The Journal of Nutrition·D A HanesM E Wastney
Jan 23, 1999·The Journal of Nutrition·D A HanesM Wastney
Apr 12, 2000·Journal of the American College of Nutrition·L Guéguen, A Pointillart
Jan 4, 2001·Trends in Endocrinology and Metabolism : TEM·L K Bachrach
May 15, 2001·Journal of the American College of Nutrition·G D MillerL D McBean
May 23, 2001·Experimental Biology and Medicine·K Y Patterson, C Veillon
May 16, 2002·Physiologia Plantarum·Matthew D Kleinhenz, Jiwan P Palta
Sep 1, 1992·The Plant Cell·V. Raz, R. Fluhr
Dec 24, 2002·The Journal of Biological Chemistry·Toshiro ShigakiKendal D Hirschi
Mar 6, 2004·Molecular Plant-microbe Interactions : MPMI·Shuji TaniHoward S Judelson
Jul 9, 2004·The Journal of Pediatrics·Ana M Avalos MishaanSteven A Abrams
Jul 5, 2005·The Journal of Biological Chemistry·Toshiro ShigakiKendal D Hirschi
Jul 7, 2005·Journal of Agricultural and Food Chemistry·Sunghun ParkKendal D Hirschi
Jul 23, 2005·IUBMB Life·Jacques-Henry Weil
Oct 5, 2006·Biotechnology & Genetic Engineering Reviews·William Freese, David Schubert
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dean DellaPenna
Jul 31, 2007·International Journal of Epidemiology·Chan Frank Wan KinWoo Jean
Sep 28, 2007·Journal of Experimental Botany·Hui MeiKendal D Hirschi

❮ Previous
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Citations

Jan 21, 2011·Plant Cell Reports·Dawei YuanPaul Christou
Jul 27, 2010·Protoplasma·Maclin DayodMatthew Gilliham
Jun 11, 2011·Biochemistry·Murli ManoharKendal D Hirschi
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shaista NaqviPaul Christou
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sichul LeeGynheung An
Apr 30, 2009·Annual Review of Nutrition·Kendal D Hirschi
Nov 26, 2010·PloS One·Briardo LlorenteFernando F Bravo-Almonacid
Sep 28, 2012·Nutrients·Jian YangKendal D Hirschi
Mar 5, 2010·The American Journal of Clinical Nutrition·Steven A Abrams
Feb 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeeyon Jeong, Mary Lou Guerinot
Dec 3, 2010·Current Opinion in Biotechnology·Gemma FarrePaul Christou
Jul 7, 2009·Biotechnology Advances·Arun K Sharma, Manoj K Sharma
Jun 2, 2009·Current Opinion in Plant Biology·Alison J Karley, Philip J White
May 29, 2009·Current Opinion in Plant Biology·Fang-Jie Zhao, Steve P McGrath
Apr 3, 2009·Current Opinion in Biotechnology·Antonio J MatasJocelyn K C Rose
Mar 6, 2009·Appetite·Michael G Tordoff, Mari A Sandell
Nov 22, 2008·Plant Biotechnology Journal·Sunghun ParkKendal D Hirschi
Jan 22, 2011·EMBO Reports·Irwin L Goldman
Dec 10, 2014·Molecular Nutrition & Food Research·Filip KiekensChristophe P Stove
Dec 22, 2009·Current Opinion in Plant Biology·Gemma FarrePaul Christou
Jan 1, 2010·Biotechnology & Genetic Engineering Reviews·Wayne Martindale
Apr 23, 2010·Annals of Botany·Simon Conn, Matthew Gilliham
Jun 13, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kayo YoshimatsuMasahiro Nishijima
Apr 15, 2010·Annals of the New York Academy of Sciences·Anne S Meyer
Jun 1, 2010·The Proceedings of the Nutrition Society·Martin R Broadley, Philip J White
Jul 13, 2018·Genes·Briardo LlorenteHugh D Goold
Jul 30, 2020·The Journal of Nutrition·Kendal D Hirschi
Jul 19, 2008·Trends in Plant Science·Kendal Hirschi

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